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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.9
- 수록면
- 24 - 30 (7page)
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Concern that some chemicals in our environment may affect human health by disrupting
normal endocrine function has prompted a research on interactions of environmental contaminants
with steroid hormone receptor. Toxaphene and chlordane are among the 12 persistent organic
pollutants identified by the United Nations Environment Programme as requiring urgent attention. We
compared the estrogenic activity of two organochlorine pesticides, toxaphene and chlordane, at estrogen
receptor α (ERα) and estrogen receptor β (ERβ). Human hepatoma cells (HepG2) were transiently
transfected with rat ERα or ERβ plus an estrogen-responsive complement C3-luciferase (C3-
Luc) reporter gene. After transfection, cells were treated with various concentrations of toxaphene and
chlordane to investigate agonism or antagonism of these chemicals. Both toxaphene and chlordane
were potent agonists in HepG2 cells for ERα. In contrast, these chemicals had a minimal agonist
activity with ERβ and almost abolished 17β-estradiol-induced ERβ-mediated activity. Therefore, toxaphene
and chlordane behaved as an ERα agonist and an ERβ antagonist with estrogen-responsive
reporter plasmid C3-Luc, and exposure to these organochlorine pesticides could have a crictical effect
on normal endocrine function.
normal endocrine function has prompted a research on interactions of environmental contaminants
with steroid hormone receptor. Toxaphene and chlordane are among the 12 persistent organic
pollutants identified by the United Nations Environment Programme as requiring urgent attention. We
compared the estrogenic activity of two organochlorine pesticides, toxaphene and chlordane, at estrogen
receptor α (ERα) and estrogen receptor β (ERβ). Human hepatoma cells (HepG2) were transiently
transfected with rat ERα or ERβ plus an estrogen-responsive complement C3-luciferase (C3-
Luc) reporter gene. After transfection, cells were treated with various concentrations of toxaphene and
chlordane to investigate agonism or antagonism of these chemicals. Both toxaphene and chlordane
were potent agonists in HepG2 cells for ERα. In contrast, these chemicals had a minimal agonist
activity with ERβ and almost abolished 17β-estradiol-induced ERβ-mediated activity. Therefore, toxaphene
and chlordane behaved as an ERα agonist and an ERβ antagonist with estrogen-responsive
reporter plasmid C3-Luc, and exposure to these organochlorine pesticides could have a crictical effect
on normal endocrine function.
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