지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 99 - 107 (9page)
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초록· 키워드
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Since endocrine disrupting chemicals (EDCs) may interfere with the endocrine system(s) of our body and have an estrogenicity, we evaluated the effect(s) of bisphenol A (BPA) on the transcriptional levels of altered genes in estrogen receptor (ER)-positive BG-1 ovarian cancer cells by microarray and real-time polymerase-chain reaction. In this study, treatment with 17β-estradiol (E2) or BPA increased mRNA levels of E2-responsive genes related to apoptosis, cancer and cell cycle, signal transduction and nucleic acid binding etc. In parallel with their microarray data, the mRNA levels of some altered genes including RAB31_MEMBER RAS ONCOGENE FAMILY (U59877), CYCLIN D1 (X59798), CYCLIN-DEPENDENT KINASE 4 (U37022), INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 4 (U20982), and ANTI-MULLERIAN HORMONE (NM_000479) were significantly induced by E2 or BPA in this cell model. These results indicate that BPA in parallel with E2 induced the transcriptional levels of E2-responsive genes in an estrogen receptor (ER)-positive BG-1 cells. In conclusion, these microarray and real-time polymerasechain reaction results indicate that BPA, a potential weak estrogen, may have estrogenic effect by regulating E2-responsive genes in ER-positive BG-1 cells and BG-1 cells would be the best in vitro model to detect these estrogenic EDCs.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (40)
참고문헌 신청
Choi KC / 2003 / The biomarker and endocrine disruptors in mammals / JOURNAL OF REPRODUCTION AND DEVELOPMENT 49(5):337~345
Dang VH / 2007 / Tetrabromodiphenyl ether(BDE 47) evokes estrogenicity and calbindin-D9k expressionthrough an estrogen receptor-mediated pathway in theuterus of immature rats / Toxicol Sci 97(2):504~511
Daston GP / 2003 / Uncertainties for endocrine disrupters: our view on progress / Toxicol Sci 74(2):245~252
Borgert CJ / 2003 / A critical review of methods for comparing estrogenic activity of endogenous and exogenous chemicals in human milk and infant formula / Environ Health Perspect 111(8):1020~1036
An BS / 2003 / Novel Calbindin-D(9k) protein as a useful biomarker for environmental estrogenic compounds in the uterus of immature rats / Reprod Toxicol 17(3):311~319
Dang VH / 2007 / Tetrabromodiphenyl ether(BDE 47) evokes estrogenicity and calbindin-D9k expressionthrough an estrogen receptor-mediated pathway in theuterus of immature rats / Toxicol Sci 97(2):504~511
Daston GP / 2003 / Uncertainties for endocrine disrupters: our view on progress / Toxicol Sci 74(2):245~252
Borgert CJ / 2003 / A critical review of methods for comparing estrogenic activity of endogenous and exogenous chemicals in human milk and infant formula / Environ Health Perspect 111(8):1020~1036
An BS / 2003 / Novel Calbindin-D(9k) protein as a useful biomarker for environmental estrogenic compounds in the uterus of immature rats / Reprod Toxicol 17(3):311~319
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UCI(KEPA) : I410-ECN-0101-2013-510-000557304