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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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It was researched to react horse serum-BChE with hexanoylthiocholine chosen among choline esters. According as
number of carbon of acyl group in choline esters was increased, reactivity was decreased but strength of ES complex was increased (Km=0.140mM). The pH-V/K profile for BChE-catalyzed hydrolysis of hexanoylthiocholine yields a pKa=4.974±0.028. This value is equal to recent literature that shows systematic shift from dependence of activity on the basic form fo a residue that has a pKa=6.2∼6.4 to catalysis by a residue or residues that has a pKa=4.7∼5.0. The
resulting kinetic solvent isotope effect of hexanoylthiocholine is DV/K=1.18. The magnitude of the isotope effect suggests that proton transfer is not an element of transition-state stabilization.
number of carbon of acyl group in choline esters was increased, reactivity was decreased but strength of ES complex was increased (Km=0.140mM). The pH-V/K profile for BChE-catalyzed hydrolysis of hexanoylthiocholine yields a pKa=4.974±0.028. This value is equal to recent literature that shows systematic shift from dependence of activity on the basic form fo a residue that has a pKa=6.2∼6.4 to catalysis by a residue or residues that has a pKa=4.7∼5.0. The
resulting kinetic solvent isotope effect of hexanoylthiocholine is DV/K=1.18. The magnitude of the isotope effect suggests that proton transfer is not an element of transition-state stabilization.
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UCI(KEPA) : I410-ECN-0101-2009-470-013836632