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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.3
- 수록면
- 54 - 59 (6page)
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We have used cDNA microarray hybridization to identify gene regulated in response to gammairradiation in U-937 cell. The cDNA-chip was composed entirely of 1,000 human cancer related gene including apoptosis and angiogenesis etc. In gamma-irradiated U-937 cell, highly charged protein, ribosomal protein L32, four and a half LIM domains 3, lipocalin 2 (oncogene 24p3) and interleukin 15, ataxia telangiectasia mutated (includes complementation groups A, C and D) genes showed increased level of its transcription, and cell division cycle 25A, dihydrofolate reductase, topoisomerase (DNA) II beta(180kD), kinase suppressor of ras and strarigin genes showed reduced level of its transcription compared to untreated U-937 cell. The significant change of level of transcription was not found in well-known ionizing radiation(IR)-responsive gene, such as
transcription factor TP53 and p53 related gene, except ataxia telangiectasia mutated gene.
transcription factor TP53 and p53 related gene, except ataxia telangiectasia mutated gene.
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U-937 세포에서 이온화 방사선의 조사선량에 따른 감수성 유전자들의 발현 변화
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UCI(KEPA) : I410-ECN-0101-2009-476-013751467