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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 54 - 62 (9page)
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초록· 키워드
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Purpose: Gastric cancer is one of the most prevalent cancers worldwide. 5-fluorouracil (5-FU) and cisplatin are the most commonly used drugs for the treatment of gastric cancer. However, a significant number of tumors often fail to respond to chemotherapy. Materials and Methods: To better understand the molecular mechanisms underlying drug resistance in gastric cancer the gene expression in gastric cancer cells, which were either sensitive or resistant to 5-FU and cisplatin, were examined using cDNA microarray analysis. To confirm the differential gene expression, as determined using the microarray, semiquantitative RT-PCR was performed on a subset of differentially expressed cDNAs. Results: 69 and 45 genes, which were either up-regulated (9 and 22 genes) or down-regulated (60 and 25 genes), were identified in 5-FU- and cisplatin-resistant cells, respectively. Several genes, such as adaptor-related protein complex 1 and baculoviral IAP repeat-containing 3, were up-regulated in both drug-resistant cell types. Several genes, such as the ras homolog gene family, tropomyosin, tumor rejection antigen, protein disulfide isomerase-related protein, melanocortin 1 receptor, defensin, cyclophilin B, dual specificity phosphatase 8 and hepatocyte nuclear factor 3, were down-regulated in both drug- resistant cell types. Conclusion: These findings show that cDNA microarray analysis can be used to obtain gene expression profiles that reflect the effect of anticancer drugs on gastric cancer cells. Such data may lead to the assigning of signature expression profiles of drug-resistant tumors, which may help predict responses to drugs and assist in the design of tailored therapeutic regimens to overcome drug resistance.
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참고문헌 (23)
참고문헌 신청
/ 1991 / Biology of the multidrug resistance-associated protein : 945 ~ 57
/ 1994 / Characterization of resistancemechanisms to cis-diamminedichloroplatinum in threesublines of the CC531 colon adenocarcinoma cell line in vitro : 487 ~ 93
/ 1994 / Platinum resistance. Experimental andclinical status. : 411 ~ 29
/ 1996 / DNA repair:enzymatic mechanisms andrelevance to drug response 88 : 346 ~ 60
/ 1996 / Epidemiology of gastric cancer 23 : 281 ~ 91
/ 1994 / Characterization of resistancemechanisms to cis-diamminedichloroplatinum in threesublines of the CC531 colon adenocarcinoma cell line in vitro : 487 ~ 93
/ 1994 / Platinum resistance. Experimental andclinical status. : 411 ~ 29
/ 1996 / DNA repair:enzymatic mechanisms andrelevance to drug response 88 : 346 ~ 60
/ 1996 / Epidemiology of gastric cancer 23 : 281 ~ 91
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