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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2001.9
- 수록면
- 149 - 155 (7page)
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이 논문의 연구 히스토리 (3)
2002
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Eighty-one workers including 38 employees directly incinerating industry wastes were recruited from a company located in South Korea. To evaluate the association between urinary 1-hydroxypyrene glucuronide (1-OHPG) levels, as internal dose of polycyclic aromatic hydrocarbon (PAH) exposure, and glycophorin A (GPA) mutation frequency, as an early biologic effect indicator. Urinary 1-OHPG levels were measured by synchronous fluorescence spectroscopy after immunoaffinity purification using monoclonal antibody 8E11. Erythrocyte GPA variant frequency (NN or NO) was assessed in MN heterozygotes with a flow cytometic assay. The GSTM1 and GSTT1 genotypes were assessed by a multiplex PCR method. The GPA NN phenotype frequency was higher in occupationally exposed group (n=14, mean±S.D. 6.6±12.0 in 106 erythrocyte cells)
than in non-exposed group (n=22, 2.1±3.5). Similarly, the GPA(NO or NN) phenotype frequency was higher in exposed group (n=14, 9.7±17.3) than non-exposed group (n=22, 4.2 ± 6.3). The above differences failed to reach statistical significance, but a significant increase was seen in GPA variant frequency levels with increase in urinary 1-OHPG levels (Spearman's correlation: p=0.06 (NO), p=0.07 (NO or NN)). When this association was evaluated by GSTM1 genotype status, the association between GPA mutation and urinary 1-OHPG levels was stronger in individuals with GSTM1 present genotype (Spearmans correlation; r=0.50, p=0.02). These
results suggest that the association between urinary 1-OHPG and GPA mutation is be modulated by the GSTM1 genotype.
than in non-exposed group (n=22, 2.1±3.5). Similarly, the GPA(NO or NN) phenotype frequency was higher in exposed group (n=14, 9.7±17.3) than non-exposed group (n=22, 4.2 ± 6.3). The above differences failed to reach statistical significance, but a significant increase was seen in GPA variant frequency levels with increase in urinary 1-OHPG levels (Spearman's correlation: p=0.06 (NO), p=0.07 (NO or NN)). When this association was evaluated by GSTM1 genotype status, the association between GPA mutation and urinary 1-OHPG levels was stronger in individuals with GSTM1 present genotype (Spearmans correlation; r=0.50, p=0.02). These
results suggest that the association between urinary 1-OHPG and GPA mutation is be modulated by the GSTM1 genotype.
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