Genetic Polymorphisms of GSTM1 and GSTT1 Genes in Delhi and Comparison with other Indian and Global Populations

Sharma, Anita; Pandey, Arvind; Sardana, Sarita; Sehgal, Ashok; Sharma, Joginder K.

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저자정보: Sharma, Anita (Division of Molecular Diagnostics, Institute of Cytology and Preventive Oncology) Pandey, Arvind (Centre for Biotechnology, University of Allahabad) Sardana, Sarita (Division of Epidemiology and Biostatistics, Institute of Cytology and Preventive Oncology) Sehgal, Ashok (Division of Epidemiology and Biostatistics, Institute of Cytology and Preventive Oncology) Sharma, Joginder K. (Division of Molecular Diagnostics, Institute of Cytology and Preventive Oncology)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제11호

발행연도: 2012.1

수록면: 5,647 - 5,652 (6page)

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The glutathione S-transferases (GSTs) are involved in the metabolism of many xenobiotics, including an array of environmental carcinogens, pollutants, and drugs. Genetic polymorphisms in these genes may lead to inter-individual variation in susceptibility to various diseases. In the present study, GSTM1 and GSTT1 polymorphisms were analysed using a multiplex polymerase chain reaction in 500 normal individuals from Delhi. The frequency of individuals with GSTM1 and GSTT1 null genotypes were 168 (33.6%) and 62 (12.4%) respectively, and 54(10.8%) were having homozygous null genotype for both the genes GSTM1 and GSTT1simultaneously. The studied population was compared with reported frequencies from other neighbouring state populations, as well as with those from other ethnic groups; Europeans, Blacks, and Asians. The prevalence of homozygous null GSTM1 genotype is significantly higher in Caucasians and Asians as compared to Indian population. The frequency of GSTT1 homozygous null genotypes is also significantly higher in blacks and Asians. We believe that due to large number of individuals in this study, our results are reliable estimates of the frequencies of the GSTM1, GSTT1 in Delhi. It would provide a basic database for future clinical and genetic studies pertaining to susceptibility and inconsistency in the response and/or toxicity to drugs known to be the substrates for GSTs.

#GSTM1 #GSTT1 #GSTP1 #polymorphism #North Indians

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