지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 161 - 166 (6page)
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초록· 키워드
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Early growth response (Egr)-1 is a Cys2-His₂-type zincfinger transcription factor. It has been shown to induce survival and proliferation of immature and mature B cells, respectively, but its role in the differentiation of B cells into plasma cells remains unclear. To examine the effects of Egr-1 deficiency on the activation of B cells, naive B cells from Egr1<SUP>?/?</SUP> mice and their wild-type (WT) littermates were activated to proliferate and differentiate, and then assayed by FACS. Proportions of cells undergoing proliferation and apoptosis did not differ between Egr1<SUP>?/?</SUP> and WT mice. However, Egr1<SUP>?/?</SUP> B cells gave rise to fewer plasma cells than WT B cells. Consistently, Egr1<SUP>?/?</SUP> mice produced significantly lower titer of antigen-specific IgG than their WT littermates upon immunization. Our results demonstrate that Egr-1 participates in the differentiation program of B cells into plasma cells, while it is dispensable for the proliferation and survival of mature B cells.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (16)
참고문헌 신청
[학술지(정기간행물)] - Tarlinton, D. / 2008 / Plasma cell differentiation survival / Curr. Opin. Immunol 20 : 162 ~ 169
[학술지(정기간행물)] - Gomez-Martin, D. / 2010 / Early growth response transcription factors the modulation of immune response: implications towards autoimmunity / Autoimmun. Rev 9 : 454 ~ 458
[학술지(정기간행물)] - Adamson, E. / 2003 / Egr1 signaling in prostate cancer / Cancer Biol. Ther 2 : 617 ~ 622
[학술지(정기간행물)] - Virolle, T. / 2003 / Egr1 promotes growth survival of prostate cancer cells. Identification of novel Egr1 target genes / J. Biol. Chem 278 : 11802 ~ 11810
[학술지(정기간행물)] - Adamson, E. D. / 2002 / Egr1 transcription factor:multiple roles in prostate tumor cell growth survival / Tumour Biol 23 : 93 ~ 102
[학술지(정기간행물)] - Gomez-Martin, D. / 2010 / Early growth response transcription factors the modulation of immune response: implications towards autoimmunity / Autoimmun. Rev 9 : 454 ~ 458
[학술지(정기간행물)] - Adamson, E. / 2003 / Egr1 signaling in prostate cancer / Cancer Biol. Ther 2 : 617 ~ 622
[학술지(정기간행물)] - Virolle, T. / 2003 / Egr1 promotes growth survival of prostate cancer cells. Identification of novel Egr1 target genes / J. Biol. Chem 278 : 11802 ~ 11810
[학술지(정기간행물)] - Adamson, E. D. / 2002 / Egr1 transcription factor:multiple roles in prostate tumor cell growth survival / Tumour Biol 23 : 93 ~ 102
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UCI(KEPA) : I410-ECN-0101-2016-511-001754693