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논문 기본 정보

자료유형
학술저널
저자정보
Ghoreishy Seyed Mojtaba (Student Research Committee, School of Public Health, Iran University of Medical Sciences, Tehran 14665-354, Iran.Department of Nutrition, School of Public Health, Iran University of Medical) Zeraattalab-Motlagh Sheida (Department of Health) Amiri Khosroshahi Reza (Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran 14155-6117, Iran.) Hemmati Amirhossein (Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran 14155-6117, Iran.) Noormohammadi Morvarid (Student Research Committee, School of Public Health, Iran University of Medical Sciences, Tehran 14665-354, Iran.Department of Nutrition, School of Public Health, Iran University of Medical) Mohammadi Hamed (Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran 14155-6117, Iran.)
저널정보
한국임상영양학회 Clinical Nutrition Research Clinical Nutrition Research Vol.13 No.3
발행연도
2024.7
수록면
186 - 200 (15page)
DOI
10.7762/cnr.2024.13.3.186

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Meta-analyses have been conducted with conflicting results on this topic. Due to missing several eligible studies in previous meta-analysis by Lam et al., we conducted an extensive systematic review and dose-response meta-analysis of randomized controlled trials in this regard. A comprehensive search was conducted across various databases, including MEDLINE/PubMed, ISI Web of Knowledge, Scopus, and Google Scholar, until November 2023. Based on the analysis of 33 studies comprising 2,047 individuals, it was found that there was a significant increase in body weight for each 1 g/day increase in omega-3 lipids (standardized MD [SMD], 0.52 kg; 95% confidence interval [CI], 0.31, 0.73; I2 = 95%; Grading of Recommendations Assessment, Development and Evaluation [GRADE] = low). Supplementation of omega-3 fatty acids did not yield a statistically significant impact on body mass index (BMI) (SMD, 0.12 kg/m2; 95% CI, −0.02, 0.27; I2 = 79%; GRADE = very low), lean body mass (LBM) (SMD, −0.02 kg; 95% CI, −0.43, 0.39; I2 = 97%; GRADE = very low), fat mass (SMD, 0.45 kg; 95% CI, −0.25, 1.15; I2 = 96%; GRADE = low), and body fat (SMD, 0.30%; 95% CI, −0.90, 1.51; I2 = 96%; GRADE = very low). After excluding 2 studies, the findings were significant for BMI. Regarding the results of the dose-response analysis, body weight increased proportionally by increasing the dose of omega-3 supplementation up to 4 g/day. Omega-3 fatty acid supplementation can improve body weight, but not BMI, LBM, fat mass, or body fat in cancer patients; large-scale randomized trials needed for more reliable results.

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