지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition Vol.27 No.5
- 발행연도
- 2024.9
- 수록면
- 298 - 312 (15page)
- DOI
- https://doi.org/10.5223/pghn.2024.27.5.298
이용수
초록· 키워드
오류제보하기
Purpose: Cytomegalovirus (CMV) infection affects the hepatic, neurologic, hematopoietic, respiratory, gastrointestinal, and other organs, resulting in a high mortality rate and long-term sequelae. It may cause acute or chronic hepatitis, or even lead to hepatic cirrhosis. Valganciclovir (VGCV) is an effective, safe, and well-tolerated treatment for congenital CMV infection, without any serious adverse effects. This study was conducted to evaluate the clinical, biochemical, and virological profiles of infants with CMV with intrahepatic cholestasis and to determine the outcomes with or without treatment with VGCV.
Methods: Twenty infants aged <6 months diagnosed with congenital CMV infection with evidence of intrahepatic cholestasis were included in this study. Randomization was used to divide the study participants into 2 groups. The control group (n=10) was treated with only supportive management, and the intervention group (n=10) was treated with oral VGCV at 16 mg/kg/dose 12 hours a day for 6 weeks plus supportive treatments. Physical examinations and biochemical, serological, and virological tests were performed at the time of diagnosis and at the end of 6 weeks and 6 months.
Results: The control and intervention groups were compared in terms of clinical and laboratory parameters such as jaundice, dark urine, pale stool, hepatomegaly, total bilirubin, aminotransferases, gamma-glutamyl transferase, alkaline phosphatase, and CMV polymerase chain reaction load, which showed a significant reduction after treatment in the intervention group (p<0.05) with oral VGCV, with very few side effects, whereas the control group showed no significant changes.
Conclusion: Oral VGCV can be used to effectively treat CMV infection with intrahepatic cholestasis without notable side effects.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Diagnostic Clues for Congenital Cytomegalovirus Infection: Association with Newborn Hearing Screening Tests
Neonatal medicine
2019 .01
-
건강한 4개월 영아에서 기흉으로 발현된 거대세포바이러스 폐렴 1예
Allergy Asthma & Respiratory Diseases
2021 .01
-
Laboratory diagnostic testing for cytomegalovirus infection in solid organ transplant patients
Clinical Transplantation and Research
2022 .03
-
Cytomegalovirus Infection in Pediatric Renal Transplant Recipients: A Single Center Experience
Childhood Kidney Diseases
2017 .01
-
Diagnostic Usefulness of Cytomegalovirus (CMV)- Specific T Cell Immunity in Predicting CMV Infection after Kidney Transplantation: A Pilot Proof-of- Concept Study
Infection and Chemotherapy
2015 .01
-
Emergency gastrointestinal tract operation associated with cytomegalovirus infection
Annals of Surgical Treatment and Research
2023 .02
-
Immunological Prediction of Cytomegalovirus (CMV) Replication Risk in Solid Organ Transplantation Recipients: Approaches for Regulating the Targeted Anti-CMV Prevention Strategies
Infection and Chemotherapy
2017 .01
-
Breast Milk-Transmitted Cytomegalovirus Infection in Preterm Infants
Neonatal medicine
2018 .01
-
Comparison of the Commercial QuantiFERON-CMV and Overlapping Peptide-based ELISPOT Assays for Predicting CMV Infection in Kidney Transplant Recipients
Immune Network
2017 .10
-
Audiologic Status of Children with Confirmed Cytomegalovirus Infection: a Case Series
Journal of Korean Medical Science
2020 .01
-
Prevention of Cytomegalovirus Infection in Solid Organ Transplant Recipients: Guidelines by the Korean Society of Infectious Diseases and the Korean Society for Transplantation
Infection and Chemotherapy
2024 .03
-
Cytomegalovirus Infection after Renal Transplantation: Occurrence, Clinical Features, and the Cutoff for Antigenemia in a University Hospital in Brazil
Infection and Chemotherapy
2017 .01
-
The Detailed Kinetics of Cytomegalovirus-specific T cell Responses after Hematopoietic Stem Cell Transplantation : 1 Year Follow-up Data
Immune Network
2018 .04
-
Clinical Usefulness of Monitoring Cytomegalovirus-Specific Immunity by Quantiferon-CMV in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation Recipients
Annals of Laboratory Medicine
2017 .01
-
Disseminated Postnatal Cytomegalovirus Infection in a Preterm Neonate: Autopsy Case Report
Neonatal medicine
2021 .01
-
인간거대세포바이러스 DNA 정량 중합효소연쇄반응 검사의 실제
Annals of Clinical Microbiology
2017 .01
-
Prevention of Cytomegalovirus Transmission via Breast Milk in Extremely Low Birth Weight Infants
Yonsei Medical Journal
2015 .01
-
Human Cytomegalovirus Infection in Solid-Organ Transplantation
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .03
-
A Case Treated with Extracorporeal Membrane Oxygenation for Disseminated Cytomegalovirus Infection after Liver Transplantation
Clinical Transplantation and Research
2017 .01
-
Effectiveness of valacyclovir prophylaxis against the occurrence of cytomegalovirus infection in kidney transplant recipients
Clinical Transplantation and Research
2020 .01
최근 본 자료
댓글(0)
0