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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 15 - 23 (9page)
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Background: Cytomegalovirus (CMV) infection is a crucial infection in kidney transplant recipients (KTRs) despite advancements in diagnostic and treatment methods. There are still many controversies about the ways to prevent CMV infection. Methods: We retrospectively analyzed 153 KTRs who underwent kidney transplantation (KT) between September 2013 and January 2016. We classified KTRs into two groups: valacyclovir prophylaxis group (intravenous ganciclovir for 2 weeks after KT, followed by oral valacyclovir for 3 months) and historical control group (only intravenous ganciclovir for 2 weeks after KT). We evaluated the incidence of CMV infection, clinical outcomes, CMV-free survival rate between the two groups and risk factors for the development of CMV infection. Results: Mean time between KT and diagnosis of CMV infection was 4.5±3.3 months. The valacyclovir prophylaxis group showed lower incidence of CMV infection than the historical control group (21.7% vs. 43.9%, P=0.011). The valacyclovir prophylaxis group showed higher CMV-free survival rate than the control group (P=0.011). In multivariable- adjusted analysis, independent risk factors for the development of CMV infection were no valacyclovir prophylaxis, older age at KT, thymoglobulin induction, and delayed graft function. Conclusions: Valacyclovir prophylaxis for 3 months showed significant reduction in the incidence of CMV infection in KTRs. Therefore, we suggest valacyclovir prophylaxis for 3 months in KTRs with risk factors such as old age, thymoglobulin induction, and delayed graft function.
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참고문헌 (16)
참고문헌 신청
Fishman JA / 2007 / Infection in solid-organ transplant recipients / N Engl J Med 357:2601~2614
Hill P / 2017 / Polyclonal and monoclonal antibodies for induction therapy in kidney transplant recipients / Cochrane Database Syst Rev 1:CD004759
De Keyzer K / 2011 / Human cytomegalovirus and kidney transplantation : a clinician's update / Am J Kidney Dis 58:118~126
Freeman RB Jr / 2009 / The 'indirect' effects of cytomegalovirus infection / Am J Transplant 9:2453~2458
Sagedal S / 2002 / The impact of cytomegalovirus infection and disease on rejection episodes in renal allograft recipients / Am J Transplant 2:850~856
Hill P / 2017 / Polyclonal and monoclonal antibodies for induction therapy in kidney transplant recipients / Cochrane Database Syst Rev 1:CD004759
De Keyzer K / 2011 / Human cytomegalovirus and kidney transplantation : a clinician's update / Am J Kidney Dis 58:118~126
Freeman RB Jr / 2009 / The 'indirect' effects of cytomegalovirus infection / Am J Transplant 9:2453~2458
Sagedal S / 2002 / The impact of cytomegalovirus infection and disease on rejection episodes in renal allograft recipients / Am J Transplant 2:850~856
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