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논문 기본 정보

자료유형
학술저널
저자정보
Su Jin You (Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Danbee Kang (Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University) Ji-Hee Sung (Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Hyejeong Park (Department of Center for Clinical Epidemiology, Samsung Medical Center) Juhee Cho (Department of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University) Suk-Joo Choi (Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Soo-Young Oh (Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine) Cheong-Rae Roh (Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
저널정보
대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science Vol.67 No.4
발행연도
2024.7
수록면
380 - 392 (13page)
DOI
10.5468/ogs.24005

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초록· 키워드

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Objective To assess the influence of advanced maternal age on congenital malformations, short- and long-term outcomes in offspring of nulligravida. Methods A retrospective study was conducted using the Korean National Health Insurance Service database spanning from January 2005 to December 2019. All live-born offspring of nulligravida (n=3,685,817) were included. The maternal age was subdivided into the following subgroups: <25 years (n=153,818), 25-29 years (n=845,355), 30-34 years (n=1,738,299), 35-39 years (n=787,530), 40-44 years (n=151,519), and >44 years (n=9,296). Outcomes were assessed based on International Classification of Diseases-10 codes. Adjusted odds ratios (aOR) were calculated with the group of 25-29 years as a reference. Result Most congenital malformations showed an age dependent increase, but cleft lip and abdominal wall defect exhibited a U-shape curve, indicating an increase even in those <25 years old. Similarly, various disorders included in the neonatal composite outcomes from short-term outcomes showed aged dependent escalation. However, the preterm birth from the short-term outcome and most of the long-term developmental outcomes, except for motor developmental delay and Tics, showed a U-shaped pattern. The aOR of autism and cerebral palsy, showing the most obvious U-shaped curved in the long-term outcomes, was 1.50 (95% confidence interval [CI], 1.24-1.82) and 1.54 (95% CI, 1.17-2.03), respectively in the group >44 years old and 1.18 (95% CI, 1.11-1.25) and 1.19 (95% CI, 1.09-1.30) in <25 years old group. Conclusion Overall, an advanced maternal age has an age-dependent correlation with most congenital malformations and shortand long-term outcomes of neonates.

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