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논문 기본 정보

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학술저널
저자정보
Suzuki Noritaka (Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan) Eguchi Yawara (Graduate School of Medicine, Chiba University, Chiba, Japan) Hirai Takashi (Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan) Takahashi Takuya (Orthopaedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan) Takahashi Yohei (Orthopaaedic Surgery, Keio University School of Medicine, Tokyo, Japan) Watanabe Kota (Keio University School of Medicine, Tokyo, Japan) Banno Tomohiro (Hamamatsu University School of Medicine) Sakaki Kyohei (Orthopaedic Surgery, Saiseikai Kawaguchi General Hospital, Kawaguchi, Japan) Maki Satoshi (Graduate School of Medicine, Chiba University) Takano Yuuichi (Orthopaedic Surgery, Inanami Spine and Joint Hospital, Tokyo, Japan) Taniguchi Yuki (Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo, Japan) Aoki Yasuchika (Eastern Chiba Medical Center, Togane, Japan) Konishi Takamitsu (Orthopaedic Surgery, Tokyo Medical University, Tokyo, Japan) Hiraizumi Yutaka (Orthopaedic Surgery, Showa University School of Medicine, Tokyo, Japan) Yamagata Masatsune (Oyumino Central Hospital Mobara Clinic, Mobara, Japan) Hirakawa Akihiro (Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan) Ohtori Seiji (Graduate School of Medicine, Chiba University)
저널정보
대한척추외과학회 Asian Spine Journal Asian Spine Journal Vol.18 No.4
발행연도
2024.8
수록면
550 - 559 (10page)
DOI
10.31616/asj.2024.0042

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초록· 키워드

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Study Design: Retrospective cohort study.Purpose: This study aimed to compare data from patients who received intradiscal condoliase (chondroitin sulfate ABC endolyase) injection for primary lumbar disc herniation (LDH) and recurrent LDH.Overview of Literature: Chemonucleolysis with condoliase for LDH is a treatment with relatively good results and a high safety profile; however, few studies have reported recurrence after LDH surgery.Methods: The study participants were 249 patients who underwent intradiscal condoliase injection for LDH at nine participating institutions, including 241 patients with initial LDH (group C) and eight with recurrent LDH (group R). Patient characteristics including age, sex, body mass index, disease duration, intervertebral LDH level, smoking history, and diabetes history were evaluated. Low back pain/leg pain Numerical Rating Scale (NRS) scores and the Oswestry Disability Index (ODI) were used to evaluate clinical symptoms before treatment and at 6 months and 1 year after treatment.Results: Low back pain NRS scores (before treatment and at 6 months and 1 year after treatment, respectively) in group C (4.9 → 2.6 → 1.8) showed significant improvement until 1 year after treatment. Although a tendency for improvement was observed in group R (3.5 → 2.8 → 2.2), no significant difference was noted. Groups C (6.6 → 2.4 → 1.4) and R (7.0 → 3.1 → 3.2) showed significant improvement in the leg pain NRS scores after treatment. Group C (41.4 → 19.5 → 13.7) demonstrated significant improvement in the ODI up to 1 year after treatment; however, no significant difference was found in group R (35.7 → 31.7 → 26.4).Conclusions: Although intradiscal condoliase injection is less effective for LDH recurrence than for initial cases, it is useful for improving leg pain and can be considered a minimally invasive and safe treatment method.

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