지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.99 No.3
- 발행연도
- 2020.9
- 수록면
- 161 - 170 (10page)
이용수
초록· 키워드
오류제보하기
Purpose: The purpose of our study was initially to explore the prognostic role of LDH-to-albumin ratio in patients with colorectal carcinoma (CRC) undergoing curative resection.
Methods: The retrospective study included 295 CRC patients that underwent curative resection. According to time-dependent receiver operating characteristics (ROC) analysis, the optimal cutoff value for pretreatment LDH-to-albumin ratio was 52.7. Cox regression univariate and multivariate analyses were utilized to analyze the prognostic factors for disease-free survival (DFS) and overall survival (OS).
Results: The 295 participants included 117 women (39.7%) and had an overall mean age of 55.8 ± 14.1 years. The median follow-up period was 31.8 ± 21 months (range, 6–78 months) and 53 patients (18.0%) died from cancer during the followup period. The 5-year DFS and OS rates were 65.4% and 68.5% in patients with LDH-to-albumin ratio <52.7 (n = 152), and were 55.2% and 55.4% in patients with LDH-to-albumin ratio ≥52.7 (n = 143), respectively. Kaplan-Meier curves showed that LDH-to-albumin ratio ≥52.7 was significantly associated with worse DFS and OS (P = 0.003 and P < 0.001, respectively). Multivariate analyses revealed that LDH-to-albumin ratio was an independent predictor of resectable CRC (odds ratio, 2.104; 95% confidence interval, 1.112–3.982; P = 0.022).
Conclusion: Our study revealed that high pretreatment LDH-to-albumin ratio level was an unfavorable prognosticator in patients with CRC undergoing curative resection. LDH-to-albumin ratio is a candidate to be a prognostic biomarker in clinical practice.
Methods: The retrospective study included 295 CRC patients that underwent curative resection. According to time-dependent receiver operating characteristics (ROC) analysis, the optimal cutoff value for pretreatment LDH-to-albumin ratio was 52.7. Cox regression univariate and multivariate analyses were utilized to analyze the prognostic factors for disease-free survival (DFS) and overall survival (OS).
Results: The 295 participants included 117 women (39.7%) and had an overall mean age of 55.8 ± 14.1 years. The median follow-up period was 31.8 ± 21 months (range, 6–78 months) and 53 patients (18.0%) died from cancer during the followup period. The 5-year DFS and OS rates were 65.4% and 68.5% in patients with LDH-to-albumin ratio <52.7 (n = 152), and were 55.2% and 55.4% in patients with LDH-to-albumin ratio ≥52.7 (n = 143), respectively. Kaplan-Meier curves showed that LDH-to-albumin ratio ≥52.7 was significantly associated with worse DFS and OS (P = 0.003 and P < 0.001, respectively). Multivariate analyses revealed that LDH-to-albumin ratio was an independent predictor of resectable CRC (odds ratio, 2.104; 95% confidence interval, 1.112–3.982; P = 0.022).
Conclusion: Our study revealed that high pretreatment LDH-to-albumin ratio level was an unfavorable prognosticator in patients with CRC undergoing curative resection. LDH-to-albumin ratio is a candidate to be a prognostic biomarker in clinical practice.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
Arnold M / 2017 / Global patterns and trends in colorectal cancer incidence and mortality / Gut 66:683~691
Guraya SY / 2019 / Pattern, stage, and time of recurrent colorectal cancer after curative surgery / Clin Colorectal Cancer 18:e223~8
Rossi S / 2017 / Are markers of systemic inflammation good prognostic indicators in colorectal cancer? / Clin Colorectal Cancer 16:264~274
Park JH / 2018 / Staging the tumor and staging the host : a two centre, two country comparison of systemic inflammatory responses of patients undergoing resection of primary operable colorectal cancer / Am J Surg 216:458~464
Wang F / 2018 / Prognostic value of inflammationbased scores in patients receiving radical resection for colorectal cancer / BMC Cancer 18:1102
Guraya SY / 2019 / Pattern, stage, and time of recurrent colorectal cancer after curative surgery / Clin Colorectal Cancer 18:e223~8
Rossi S / 2017 / Are markers of systemic inflammation good prognostic indicators in colorectal cancer? / Clin Colorectal Cancer 16:264~274
Park JH / 2018 / Staging the tumor and staging the host : a two centre, two country comparison of systemic inflammatory responses of patients undergoing resection of primary operable colorectal cancer / Am J Surg 216:458~464
Wang F / 2018 / Prognostic value of inflammationbased scores in patients receiving radical resection for colorectal cancer / BMC Cancer 18:1102
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UCI(KEPA) : I410-ECN-0101-2020-514-001167109