지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.1
- 수록면
- 75 - 84 (10page)
이용수
초록· 키워드
오류제보하기
Importance: Enrofloxacin preparations are available for administration daily or every 3 days. This study presents clinical evidence to define which preparation is adequate to treat clinical cases of bovine respiratory disease (BRD) in calves.
Objective: To correlate the pharmacokinetics/pharmacodynamics (PK/PD) ratios of three pharmaceutical preparations of enrofloxacin with their clinical efficacy in treating BRD.
Methods: The PK/PD ratios of three enrofloxacin preparations were determined in healthy calves. Then, 48 BRD-affected calves initially treated IV with 2.2 mg/kg of flunixinmeglumine, were randomly assigned to treatment with: enrofloxacin dihydrate-hydrochloride (enro-C) 10% water suspension daily (10 mg/kg subcutaneous for three to six days); enro-C with alginate (enro-C/Al), and reference enrofloxacin (enro-R), both intended for treatment every 72-h in two occasions (10 mg/kg).
Results: The highest maximum plasma concentration (Cmax)/minimum inhibitory concentration (MIC) ratio was obtained with enro-C and the highest area under the curve (AUC)0-72/MIC ratio with enro-R, and enro-C/Al exhibited an AUC0-72/MIC smaller, but Cmax/MIC higher than enro-R. Based on repeated statistical measurements, clinical progress revealed that the best outcomes were observed with enro-C (p < 0.05), and no statistical differences resulted by comparing enro-C/Al with enro-R.
Conclusions and Relevance: If the priority in calves affected by BRD is to speed up their recovery, and despite the more significant amount of enro-C injected, using of lower doses of enrofloxacin as in the long-acting preparations is unsustainable. This study demonstrates that the clinical efficacy of enrofloxacin in cattle is optimally linked to Cmax/MIC rather than to AUC/MIC, which occurs better when injecting enro-C.
Objective: To correlate the pharmacokinetics/pharmacodynamics (PK/PD) ratios of three pharmaceutical preparations of enrofloxacin with their clinical efficacy in treating BRD.
Methods: The PK/PD ratios of three enrofloxacin preparations were determined in healthy calves. Then, 48 BRD-affected calves initially treated IV with 2.2 mg/kg of flunixinmeglumine, were randomly assigned to treatment with: enrofloxacin dihydrate-hydrochloride (enro-C) 10% water suspension daily (10 mg/kg subcutaneous for three to six days); enro-C with alginate (enro-C/Al), and reference enrofloxacin (enro-R), both intended for treatment every 72-h in two occasions (10 mg/kg).
Results: The highest maximum plasma concentration (Cmax)/minimum inhibitory concentration (MIC) ratio was obtained with enro-C and the highest area under the curve (AUC)0-72/MIC ratio with enro-R, and enro-C/Al exhibited an AUC0-72/MIC smaller, but Cmax/MIC higher than enro-R. Based on repeated statistical measurements, clinical progress revealed that the best outcomes were observed with enro-C (p < 0.05), and no statistical differences resulted by comparing enro-C/Al with enro-R.
Conclusions and Relevance: If the priority in calves affected by BRD is to speed up their recovery, and despite the more significant amount of enro-C injected, using of lower doses of enrofloxacin as in the long-acting preparations is unsustainable. This study demonstrates that the clinical efficacy of enrofloxacin in cattle is optimally linked to Cmax/MIC rather than to AUC/MIC, which occurs better when injecting enro-C.
목차
ABSTRACT
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Pharmacokinetics of enrofloxacin HCl-2H₂O (Enro-C) in dogs and pharmacokinetic/pharmacodynamic Monte Carlo simulations against Leptospira spp.
Journal of Veterinary Science
2018 .09
-
Successful treatment of recurrent subclinical mastitis in cows caused by enrofloxacin resistant bacteria by means of the sequential intramammary infusion of enrofloxacin HCl-2H₂O and ceftiofur HCl: a clinical trial
Journal of Veterinary Science
2021 .11
-
Lipopolysaccharide에 의해 과활성화된 마우스 비장세포에서 Enrofloxacin의 조절작용
Korean Journal of Veterinary Research(대한수의학회지)
2019 .07
-
Pharmacokinetic and pharmacodynamic integration of enrofloxacin against Salmonella Enteritidis after administering to broiler chicken by per-oral and intravenous routes
Journal of Veterinary Science
2019 .03
-
Preparation and evaluation of enrofloxacin microspheres and tissue distribution in rats
Journal of Veterinary Science
2015 .06
-
[Pharmacology] Antibacterial activity of enrofloxacin loaded gelatin-sodium alginate composite nanogels against intracellular Staphylococcus aureus small colony variants
Journal of Veterinary Science
2022 .05
-
대규모 한우 번식 목장에서의 10년간 송아지 폐사 원인
Korean Journal of Veterinary Research(대한수의학회지)
2015 .06
-
Low Correlation Between Vancomycin Area Under the Curve Over 24 Hours to the MIC (AUC/MIC ratio) and the Trough Concentration at Steady State in Methicillin-Resistant Staphylococcus Aureus Pneumonia
병원약사회지
2020 .01
-
[Pharmacology] Treatment of pigs with enrofloxacin via different oral dosage forms - environmental contaminations and resistance development of Escherichia coli
Journal of Veterinary Science
2022 .03
-
Optimization of Linezolid Dosing Regimens for Treatment of Vancomycin-Resistant Enterococci Infection
Infection and Chemotherapy
2021 .09
-
Evaluation and Optimization of a Serum-based Minimum Inhibitory Concentration Assay to Caspofungin in Candida albicans Clinical Isolates
대한의생명과학회지
2016 .12
-
Analysis of hematological changes in normal and diarrhea calves
한국가축위생학회지
2020 .01
-
Formulation of a rational dosage regimen of ceftiofur hydrochloride oily suspension by pharmacokineticpharmacodynamic (PK-PD) model for treatment of swine Streptococcus suis infection
Journal of Veterinary Science
2021 .11
-
젖소 송아지와 한우 송아지의 설사병 발생률 비교
한국가축위생학회지
2024 .06
-
Prepubertal growth and single nucleotide polymorphism analysis of the growth hormone gene of low birth weight Holstein calves
Journal of Veterinary Science
2018 .01
-
Population Pharmacokinetic−Pharmacodynamic Modeling of Carvedilol to Evaluate the Effect of Cytochrome P450 2D6 Genotype on the Heart Rate Reduction
Journal of Korean Medical Science
2023 .06
-
신속 진단 킷트를 활용한 한우 송아지의 설사증 원인체 검사
한국가축위생학회지
2017 .01
-
Foreign bodies in the digestive system in the diarrheic Hanwoo calves: A retrospective study
한국가축위생학회지
2022 .12
-
Magnetic nanoparticle based purification and enzyme-linked immunosorbent assay using monoclonal antibody against enrofloxacin
Journal of Veterinary Science
2015 .12
-
Fosfomycin Dosing Regimens based on Monte Carlo Simulation for Treated Carbapenem-Resistant Enterobacteriaceae Infection
Infection and Chemotherapy
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-092311084