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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 174 - 183 (10page)
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초록· 키워드
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In the present study, a serum-based minimum inhibitory concentration (MIC) testing to caspofungin was optimized and evaluated to solve the limitations of the conventional Clinical and Laboratory Standards Institute (CLSI) guideline-based antifungal agent MIC test and the usefulness of this testing for clinical application was determined. A total of 105 Candida albicans clinical isolates were used for measuring MIC to caspofungin. Results showed that growth characteristics were different according to types of serum and the mouse serum was the most suitable for this assay. In order to measure the optimal concentration of mouse serum, 0 to 100% mouse serum were added to the media during fungal culture. The optimal concentration of serum was 50% when consideration of antifungal agent administration and inoculum size, serum components and ease of hyphae separated, and the consideration of the degree of growth. In comparison of the usefulness between the conventional Alamar-modified broth microdilution MIC assay and 50% mouse serum-based MIC testing, the range of MIC<SUB>80</SUB> of the Alamar-modified broth microdilution MIC assay was 0.13~2.0 μg/mL (SD ±0.42 μg/mL) and that of the 50% mouse serum-based MIC assay was 2.0~32.0 μg/mL (SD ±9.01 μg/mL). The range of MIC<SUB>50</SUB> of the Alamar-modified broth microdilution MIC assay was 0.13~2.0 μg/mL (SD ±0.40 μg/mL) and that of the 50% mouse serum-based MIC assay was 1.0~16.0 μg/mL (SD ±2.36 μg/mL). The MICs of 50% mouse serum-based MIC testing was increased by up to 4 to 64 times than Alamar-modified broth microdilution MIC assay. In conclusion, a 50% mouse serum-based MIC assay was more useful for measuring MIC in Candida albicans clinical isolates than conventional colorimetric broth microdilution MIC testing.
목차
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (17)
참고문헌 신청
[학술지(정기간행물)] - Espinel-Ingroff A / 2007 / Quality control and reference guidelines for CLSI broth microdilution method (M38-A document) for susceptibility testing of anidulafungin against molds / J Clin Microbiol 45 : 2180 ~ 2182
[학술지(정기간행물)] - Foldi R / 2012 / Effect of 50% human serum on the killing activity of micafungin against eight Candida species using time-kill methodology / Diagn Microbiol Infect Dis 73 : 338 ~ 342
[학술지(정기간행물)] - Healy CM / 2005 / Impact of fluconazole prophylaxis on incidence and outcome of invasive candidasis in a neonatal intensive care unit / J Pediatr 147 : 166 ~ 171
[학술지(정기간행물)] - Kanafani ZA / 2008 / Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact / Clin Infect Dis 46 : 120 ~ 128
[학술지(정기간행물)] - Odabasi Z / 2007 / Effects of serum on in vitro susceptibility testing of echomocandins / Antimicrob Agents Chemother 51 : 4214 ~ 4216
[학술지(정기간행물)] - Foldi R / 2012 / Effect of 50% human serum on the killing activity of micafungin against eight Candida species using time-kill methodology / Diagn Microbiol Infect Dis 73 : 338 ~ 342
[학술지(정기간행물)] - Healy CM / 2005 / Impact of fluconazole prophylaxis on incidence and outcome of invasive candidasis in a neonatal intensive care unit / J Pediatr 147 : 166 ~ 171
[학술지(정기간행물)] - Kanafani ZA / 2008 / Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact / Clin Infect Dis 46 : 120 ~ 128
[학술지(정기간행물)] - Odabasi Z / 2007 / Effects of serum on in vitro susceptibility testing of echomocandins / Antimicrob Agents Chemother 51 : 4214 ~ 4216
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UCI(KEPA) : I410-ECN-0101-2017-510-002026382