Pharmacokinetic and pharmacodynamic integration of enrofloxacin against Salmonella Enteritidis after administering to broiler chicken by per-oral and intravenous routes

JeongWoo Kang; Md Akil Hossain; Hae-chul Park; YongSang Kim; Kwang-jick Lee; Sung-won Park

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자료유형: 학술저널

저자정보: JeongWoo Kang (Animal and Plant Quarantine Agency) Md Akil Hossain (Animal and Plant Quarantine Agency) Hae-chul Park (Animal and Plant Quarantine Agency) YongSang Kim (Animal and Plant Quarantine Agency) Kwang-jick Lee (Animal and Plant Quarantine Agency) Sung-won Park (Animal and Plant Quarantine Agency)

저널정보: 대한수의학회 Journal of Veterinary Science Journal of Veterinary Science 제20권 제2호

발행연도: 2019.3

수록면: 135 - 146 (12page)

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It is crucial to optimize the dose of fluoroquinolones to avoid antibiotic resistance and to attain clinical success. We undertook this study to optimize the dose of enrofloxacin against Salmonella enterica subsp. enterica serovar Enteritidis (S. Enteritidis) in chicken by assessing its pharmacokinetic/pharmacodynamic (PK/PD) indices. The antibacterial activities of enrofloxacin against S. Enteritidis were evaluated. After administering 10 mg/kg body weight (b.w.) of enrofloxacin to broiler chickens of both sexes by intravenous (IV) and peroral (PO) routes, blood samples were drawn at different intervals and enrofloxacin concentrations in plasma were determined. PK/PD indices were calculated by integrating the PK and PD data. The elimination half-lives (T1/2), time required to reach peak concentration (Tmax), peak concentration (Cmax), and area under curve (AUC) after administering enrofloxacin by PO and IV routes were 25.84 ± 1.40 h, 0.65 ± 0.12 h, 3.82 ± 0.59 μg/mL, and 20.84 ± 5.0 μg·h/mL, and 12.84 ± 1.4 h, 0.22 ± 0.1 h, 6.74 ± 0.03 μg/mL, and 21.13 ± 0.9 μg.h/mL, respectively. The bioavailability of enrofloxacin was 98.6% ± 8.9% after PO administration. The MICs of enrofloxacin were 0.0625–1 μg/mL against S. Enteritidis strains, and the MIC50 was 0.50 μg/mL. The Cmax/MIC50 were 7.64 ± 0.2 and 13.48 ± 0.7 and the 24 h AUC/MIC50 were 41.68 ± 0.1 and 42.26 ± 0.3 after administering the drug through PO and IV routes, respectively. The data in this study indicate that the application of 50 mg/kg b.w. of enrofloxacin to chicken through PO and IV routes with a dosing interval of 24 h can effectively cure S. Enteritidis infection, indicating the need for a 5-fold increase in the recommended dosage of enrofloxacin in chicken.

#Dose optimization #fluoroquinolones #pharmacokinetics #pharmacodynamics

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