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논문 기본 정보

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학술저널
저자정보
Sim Doo Sun (Department of Cardiovascular Medicine, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju, Korea.Cardiovascular Research Center, Chonnam National U) Cho Kyung Hoon (Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.) Hyun Dae Young (Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.) Park Dae Sung (Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.Korea Cardiovascular Stent Institute, Jangseong, Korea.) Park Jun-Kyu (CG Bio Co., Ltd., Seoul, Korea.) Byeon Dae-Heung (CG Bio Co., Ltd., Seoul, Korea.) Jo Won-Il (CG Bio Co., Ltd., Seoul, Korea.) Kim Sang-Wook (Heart and Brain Hospital, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.) Ahn Joon Ho (Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.) Lee Seung Hun (Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, Korea.) Kim Min Chul (Department of Cardiovascular Medicine, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju, Korea.Cardiovascular Research Center, Chonnam National U) Hong Young Joon (Department of Cardiovascular Medicine, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju, Korea.Cardiovascular Research Center, Chonnam National U) Kim Ju Han (Department of Cardiovascular Medicine, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju, Korea.Cardiovascular Research Center, Chonnam National U) Ahn Youngkeun (Department of Cardiovascular Medicine, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju, Korea.Cardiovascular Research Center, Chonnam National U) Jeong Myung Ho (Department of Cardiovascular Medicine, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju, Korea.Cardiovascular Research Center, Chonnam National U)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.39 No.33
발행연도
2024.8
수록면
1 - 11 (11page)
DOI
10.3346/jkms.2024.39.e234

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초록· 키워드

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Background: In patients with coronary artery disease treated with permanent polymercoated drug-eluting stents (DES), the persistent presence of a less biocompatible polymer might delay arterial healing. Thin strut polymer-free DES have the potential to improve clinical outcomes and reduce the duration of dual antiplatelet therapy (DAPT). The purpose of this first-in-human study was to assess the safety and effectiveness of a novel polymer-free DES in patients with de novo coronary lesions. The TIGERevolutioN® stent (CG Bio Co., Ltd., Seoul, Korea) consists of a cobalt chromium platform with a strut thickness of 70 μm and a surface treated with titanium dioxide onto which everolimus-eluting stent (EES) is applied abluminally (6 µg/mm of stent length) without utilization of a polymer. Methods: A total of 20 patients were enrolled, with de novo coronary lesions (stable or unstable angina) and > 50% diameter stenosis in a vessel 2.25 to 4.00 mm in diameter and ≤ 40 mm in length for angiographic, optical coherence tomography (OCT), and clinical assessment at 8 months. All patients received DAPT after stent implantation. The primary endpoint was angiographic in-stent late lumen loss (LLL) at 8 months. Results: Twenty patients with 20 lesions were treated with TIGERevolutioN®. At 8 months, in-stent LLL was 0.7 ± 0.4 mm. On OCT, percent area stenosis was 29.2 ± 9.4% and stent strut coverage was complete in all lesions. No adverse cardiovascular event occurred at 8 months. Conclusion: The new polymer-free EES was safe and effective with low LLL and excellent strut coverage at 8 months of follow-up.
#Drug-Eluting Stents #Titanium Dioxide #Polymers

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