지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 1 - 12 (12page)
- DOI
- 10.3346/jkms.2021.36.e259
이용수
초록· 키워드
오류제보하기
Background: Titanium dioxide films exhibit good biocompatibility and may be effective as drug-binding matrices for drug-eluting stents. We conducted a mid-term evaluation of a novel polymer-free everolimus-eluting stent using nitrogen-doped titanium dioxide film deposition (TIGEREVOLUTION®) in comparison with a commercial durable polymer everolimus-eluting stent (XIENCE Alpine®) in a porcine coronary restenosis model.
Methods: Twenty-eight coronary arteries from 14 mini-pigs were randomly allocated to TIGEREVOLUTION® stent and XIENCE Alpine® stent groups. The stents were implanted in the coronary artery at a 1.1?1.2:1 stent-to-artery ratio. Eleven stented coronary arteries in each group were finally analyzed using coronary angiography, optical coherence tomography, and histopathologic evaluation 6 months after stenting.
Results: Quantitative coronary analysis showed no significant differences in the preprocedural, post-procedural, and 6-month lumen diameters between the groups. In the volumetric analysis of optical coherence tomography at 6 months, no significant differences were observed in stent volume, lumen volume, and percent area stenosis between the groups.
There were no significant differences in injury score, inflammation score, or fibrin score between the groups, although the fibrin score was zero in the TIGEREVOLUTION® stent group (0 vs. 0.07 ± 0.11, P = 0.180).
Conclusion: Preclinical evaluation, including optical coherence tomographic findings 6 months after stenting, demonstrated that the TIGEREVOLUTION® stent exhibited efficacy and safety comparable with the XIENCE Alpine® stent, supporting the need for further clinical studies on the TIGEREVOLUTION® stent.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Gruntzig A / 1978 / Transluminal dilatation of coronary-artery stenosis / Lancet 1(8058):263
Torrado J / 2018 / Restenosis, stent thrombosis, and bleeding complications : navigating between Scylla and Charybdis / J Am Coll Cardiol 71(15):1676~1695
Camenzind E / 2007 / Stent thrombosis late after implantation of first-generation drug-eluting stents : a cause for concern / Circulation 115(11):1440~1455
Finn AV / 2007 / Vascular responses to drug eluting stents : importance of delayed healing / Arterioscler Thromb Vasc Biol 27(7):1500~1510
Yazdani SK / 2011 / In vitro and in vivo characterisation of biodegradable polymer-based drug-eluting stent / EuroIntervention 7(7):835~843
Torrado J / 2018 / Restenosis, stent thrombosis, and bleeding complications : navigating between Scylla and Charybdis / J Am Coll Cardiol 71(15):1676~1695
Camenzind E / 2007 / Stent thrombosis late after implantation of first-generation drug-eluting stents : a cause for concern / Circulation 115(11):1440~1455
Finn AV / 2007 / Vascular responses to drug eluting stents : importance of delayed healing / Arterioscler Thromb Vasc Biol 27(7):1500~1510
Yazdani SK / 2011 / In vitro and in vivo characterisation of biodegradable polymer-based drug-eluting stent / EuroIntervention 7(7):835~843
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