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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.7
- 수록면
- 330 - 335 (6page)
- DOI
- https://doi.org/10.5483/BMBRep.2023-0203
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초록· 키워드
오류제보하기
Arginine methylation, which is catalyzed by protein argininemethyltransferases (Prmts), is known to play a key role in variousbiological processes. However, the function of Prmts inosteogenic differentiation of mesenchymal stem cells (MSCs)has not been clearly understood. In the current study, weattempted to elucidate a positive role of Prmt7 in osteogenicdifferentiation. Prmt7-depleted C3H/10T1/2 cells or bone marrowmesenchymal stem cells (BMSCs) showed the attenuatedexpression of osteogenic specific genes and Alizarin red stainingcompared to the wild-type cells. Furthermore, we foundthat Prmt7 deficiency reduced the activation of bone morphogeneticprotein (BMP) signaling cascade, which is essential forthe regulation of cell fate commitment and osteogenesis. Takentogether, our data indicate that Prmt7 plays important regulatoryroles in osteogenic differentiation.
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