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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 319 - 323 (5page)
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초록· 키워드
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Mesenchymal stem cells (MSCs) are multipotent stem cells capable of differentiating into adipocytes, osteoblasts, or chondrocytes.
A mutually inhibitory relationship exists between osteogenic and adipogenic lineage commitment and differentiation.
Such cell fate decision is regulated by several signaling pathways, including Wnt and bone morphogenetic protein (BMP). Accumulating evidence indicates that microRNAs (miRNAs) act as switches for MSCs to differentiate into either osteogenic or adipogenic lineage. Different miRNAs have been reported to regulate a master transcription factor for osteogenesis, such as Runx2, as well as molecules in the Wnt or BMP signaling pathway, and control the balance between osteoblast and adipocyte differentiation. Here, we discuss recent advancement of the cell fate decision of MSCs by miRNAs and their targets.
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참고문헌 (42)
참고문헌 신청
Wu T / 2012 / miR-30 family members negatively regulate osteoblast differentiation / J Biol Chem 287:7503~7511
Wang J / 2013 / miR-30e reciprocally regulates the differentiation of adipocytes and osteoblasts by directly targeting low-density lipoprotein receptor-related protein 6 / Cell Death Dis 4:e845
Li H / 2013 / miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells / Stem Cell Res 10:313~324
Komori T / 1997 / Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts / Cell 89:755~764
Yoshida CA / 2004 / Runx2and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog / Genes Dev 18:952~963
Wang J / 2013 / miR-30e reciprocally regulates the differentiation of adipocytes and osteoblasts by directly targeting low-density lipoprotein receptor-related protein 6 / Cell Death Dis 4:e845
Li H / 2013 / miR-17-5p and miR-106a are involved in the balance between osteogenic and adipogenic differentiation of adipose-derived mesenchymal stem cells / Stem Cell Res 10:313~324
Komori T / 1997 / Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts / Cell 89:755~764
Yoshida CA / 2004 / Runx2and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog / Genes Dev 18:952~963
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