지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.7
- 수록면
- 1,488 - 1,500 (13page)
- DOI
- 10.1038/s12276-024-01261-8
이용수
초록· 키워드
오류제보하기
Proinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory response, which is essential for the proper functioning of our immune system. When infections or threats to the body’s defense mechanisms are detected, the innate immune system takes the lead. However, an excessive inflammatory response can lead to the production of high concentrations of cytotoxic molecules, resulting in tissue damage. Inflammasomes are significant contributors to innate immunity, and one of the most extensively studied inflammasome complexes is NOD-like receptor 3 (NLRP3). NLRP3 has a wide range of recognition mechanisms that streamline immune activation and eliminate pathogens. These cytosolic multiprotein complexes are composed of effector, adaptor, and sensor proteins, which are crucial for identifying intracellular bacterial breakdown products and initiating an innate immune cascade. To understand the diverse behavior of NLRP3 activation and its significance in the development of lifestyle-related diseases, one must delve into the study of the immune response and apoptosis mediated by the release of proinflammatory cytokines. In this review, we briefly explore the immune response in the context of lifestyle associated disorders such as obesity, hyperlipidemia, diabetes, chronic respiratory disease, oral disease, and cardiovascular disease.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Mitophagy: a balance regulator of NLRP3 inflammasome activation
BMB Reports
2016 .01
-
The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3
Experimental and Molecular Medicine
2019 .01
-
Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination
Experimental and Molecular Medicine
2019 .01
-
STAT3 promotes NLRP3 inflammasome activation by mediating NLRP3 mitochondrial translocation
Experimental and Molecular Medicine
2024 .09
-
The activation of NLRP3 inflammasome potentiates the immunomodulatory abilities of mesenchymal stem cells in a murine colitis model
BMB Reports
2020 .01
-
Effects of α-lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation
BMB Reports
2019 .01
-
Immunomodulatory functional foods and their molecular mechanisms
Experimental and Molecular Medicine
2022 .01
-
Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
Experimental and Molecular Medicine
2023 .03
-
Autophagy down-regulates NLRP3-dependent inflammatory response of intestinal epithelial cells under nutrient deprivation
BMB Reports
2021 .01
-
Anti-inflammatory effects of N-cyclooctyl-5-methylthiazol-2-amine hydrobromide on lipopolysaccharide-induced inflammatory response through attenuation of NLRP3 activation in microglial cells
BMB Reports
2021 .11
-
Immune Designer for Dynamic Tailoring of Innate Immunity
한국고분자학회 학술대회 연구논문 초록집
2023 .10
-
Innate immune sensing of coronavirus and viral evasion strategies
Experimental and Molecular Medicine
2021 .05
-
Publisher Correction: Acetate attenuates inflammasome activation through GPR43- mediated Ca2+-dependent NLRP3 ubiquitination
Experimental and Molecular Medicine
2019 .01
-
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis
Experimental and Molecular Medicine
2022 .02
-
Remodeling and Restraining Lung Tissue Damage Through the Regulation of Respiratory Immune Responses
조직공학과 재생의학
2023 .06
-
Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing
Experimental and Molecular Medicine
2021 .11
-
MiR-146 and miR-125 in the regulation of innate immunity and inflammation
BMB Reports
2016 .01
-
Epigenetic dysregulation of immune-related pathways in cancer: bioinformatics tools and visualization
Experimental and Molecular Medicine
2021 .05
-
Immunomodulatory Biomaterials and Emerging Analytical Techniques for Probing the Immune Micro-Environment
조직공학과 재생의학
2023 .02
-
Engineering of Immune Microenvironment for Enhanced Tissue Remodeling
조직공학과 재생의학
2022 .04
최근 본 자료
댓글(0)
0