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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 529 - 535 (7page)
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The NLRP3 inflammasome is activated by a variety of external or host-derived stimuli and its activation initiates an inflammatory response through caspase-1 activation, resulting in inflammatory cytokine IL-1β maturation and secretion. The NLRP3 inflammasome activation is a kind of innate immune response, most likely mediated by myeloid cells acting as a host defense mechanism. However, if this activation is not properly regulated, excessive inflammation induced by overactivated NLRP3 inflammasome can be detrimental to the host, causing tissue damage and organ dysfunction, eventually causing several diseases. Previous studies have suggested that mitochondrial damage may be a cause of NLRP3 inflammasome activation and autophagy, which is a conserved self-degradation process that negatively regulates NLRP3 inflammasome activation.
Recently, mitochondria-selective autophagy, termed mitophagy, has emerged as a central player for maintaining mitochondrial homeostasis through the elimination of damaged mitochondria, leading to the prevention of hyperinflammation triggered by NLRP3 inflammasome activation. In this review, we will first focus on the molecular mechanisms of NLRP3 inflammasome activation and NLRP3 inflammasome-related diseases. We will then discuss autophagy, especially mitophagy, as a negative regulator of NLPP3 inflammasome activation by examining recent advances in research.
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참고문헌 (71)
참고문헌 신청
Strowig T / 2012 / Inflammasomes in health and disease / Nature 481:278~286
Lamkanfi M / 2012 / Inflammasomes and their roles in health and disease / Annu Rev Cell Dev Biol 28:137~161
Rosen H / 1979 / Bactericidal activity of a superoxide anion-generating system. A model for the polymorphonuclear leukocyte / J Exp Med 149:27~39
Chen X / 2016 / Synthesis of a highly HOCl-selective fluorescent probe and its use for imaging HOCl in cells and organisms / Nat Protoc 11:1219~1228
Yin J / 2015 / Preparation of a cyanine-based fluorescent probe for highly selective detection of glutathione and its use in living cells and tissues of mice / Nat Protoc 10:1742~1754
Lamkanfi M / 2012 / Inflammasomes and their roles in health and disease / Annu Rev Cell Dev Biol 28:137~161
Rosen H / 1979 / Bactericidal activity of a superoxide anion-generating system. A model for the polymorphonuclear leukocyte / J Exp Med 149:27~39
Chen X / 2016 / Synthesis of a highly HOCl-selective fluorescent probe and its use for imaging HOCl in cells and organisms / Nat Protoc 11:1219~1228
Yin J / 2015 / Preparation of a cyanine-based fluorescent probe for highly selective detection of glutathione and its use in living cells and tissues of mice / Nat Protoc 10:1742~1754
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