지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.12
- 수록면
- 58 - 73 (16page)
이용수
초록· 키워드
오류제보하기
Sphingosylphosphorylcholine (SPC) is one of sphingomyelin-derived sphingolipids. SPC levels are increased in ascitic fluids of ovarian cancer patients and stratum corneum of atopic dermatitis (AD) patients. SPC has antitumor activity against several cancer cells by reducing proliferation and migration and increasing apoptosis in vitro. SPC can also cause scratching, potentially exacerbating symptoms of AD. However, the role of SPC in modulating immune responses, particularly in the differentiation of Th9 cells, which carry the most powerful antitumor activity among CD4+ T cells, has yet to be investigated. In this study, we found that SPC is another inducer of Th9 cell differentiation by replicating TGF-β. SPC upregulated Smad3, STAT5, and β-catenin signaling pathways. Increased Smad3 and STAT5 signaling pathways by SPC promoted the differentiation of Th9 cells and increased β-catenin signaling pathway resulted in a less-exhausted, memory-like phenotype of Th9 cells. Increased Smad3, STAT5 and β-catenin signaling pathways by SPC were mediated by increased mitochondrial ROS. These results suggest that SPC is an important endogenous inducer of Th9 cell differentiation and may be one of the targets for treating Th9-related diseases, and that enhancing Th9 differentiation by SPC may be helpful in adoptive T cell therapy for cancer treatment.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Second primary cancers in patients with urothelial cancers
Investigative and Clinical Urology
2016 .01
-
Second Primary Cancer Risk among Kidney Cancer Patients in Korea: A Population-Based Cohort Study
Cancer Research and Treatment
2018 .01
-
Signaling web of SMADs and STAT3 in the development of arthritogenic Th17
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Oncologists’ Experience with Patients with Second Primary Cancer and the Attitudes toward Second Primary Cancer Screening: A Nationwide Survey
Cancer Research and Treatment
2015 .01
-
Single Patient Classifier Assay, Microsatellite Instability, and Epstein-Barr Virus Status Predict Clinical Outcomes in Stage II/III Gastric Cancer: Results from CLASSIC Trial
Yonsei Medical Journal
2019 .01
-
Suppression of β-catenin Signaling Pathway in Human Prostate Cancer PC3 Cells by Delphinidin
대한암예방학회지
2016 .01
-
Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells
Journal of Ginseng Research
2018 .04
-
A study on the mechanism of resistance to non-small cell lung cancer therapeutic application using mouse orthotopic model
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Clinicopathological Significance of SMAD4 Expression in Breast Cancer
Journal of Breast Disease
2019 .01
-
방사선치료에서의 품질보증을 위한 통계적공정관리의 활용
의학물리
2015 .06
-
Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/ SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
Journal of Breast Cancer
2018 .01
-
Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/ SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
Journal of Breast Cancer
2018 .01
-
T Cell-Specific Knockout of STAT3 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Reducing the Inflammatory Response
Immune Network
2018 .08
-
Roles of Signaling Pathways in the Epithelial-Mesenchymal Transition in Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
β-Catenin Alterations in Squamous Cell Carcinoma of the Lip
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Bevacizumab Regulates Cancer Cell Migration by Activation of STAT3
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Metabolic Signaling as a Driver of T Cell Aging
Immune Network
2025 .02
-
EGCG Inhibits Growth of MDA-MB-231 Breast Cancer Cell through the Inactivation of B Catenin Signaling Pathway
대한임상종양학회 학술대회지
2016 .02
-
Beta-Catenin Downregulation Contributes to Epidermal Growth Factor-induced Migration and Invasion of MDAMB231 Cells
International Journal of Oral Biology
2018 .01
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-092431778