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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.12
- 수록면
- 204 - 211 (8page)
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Marine microorganisms produce diverse bioactive compounds, including secondary me- tabolites with potential antioxidant activity, which are valuable for pharmaceutical and medical applications. In this study, Acrostalagmus luteoalbus, a marine-derived microorganism, was isolated and analyzed for its natural antioxidant properties. Using several assays, it was found that the crude extract of A. luteoalbus exhibited significant antioxidative activity, with the highest DPPH and ABTS radical scavenging effects observed in the 20% methanol fraction. High-perform- ance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy identified 3-hydroxyanthranilic acid (3-HAA) as the active compound in this fraction. 3-HAA exhibited strong reactive oxygen species (ROS) scavenging abilities and superoxide dismutase (SOD) activity, indicating its potential to mitigate oxidative damage. The cytotoxicity assay of 3-HAA using B16F10 cells confirmed its low toxicity, suggesting its potential for biomaterial applications. Furthermore, optimization of 3-HAA production revealed that a 3-day culture period at a 20‰ NaCl concentration maximized its yield. These findings underscore the potential of A. luteoalbus-derived 3-HAA as a natural antioxidant, providing foundational insights for its industrial and therapeutic development and applications.
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