지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.12
- 수록면
- 255 - 264 (10page)
- DOI
- 10.22889/KJP.2024.55.4.255
이용수
초록· 키워드
오류제보하기
Inflammation is a critical immune response to harmful stimuli such as infections or injuries. However, excessive inflammation can lead to tissue damage, chronic diseases, and systemic inflammatory response syndrome, resulting in multiple organ dysfunction. This dysregulated response can trigger a massive inflammatory cascade, which may prove fatal. Current anti-inflammatory treatments can alleviate symptoms but often have adverse effects, including gastrointestinal and cardiovascular complications. Tragopogon dubius Scop. (T. dubius) is a flowering plant from the Asteraceae family with edible stems. Despite reports of its effectiveness against periodontitis, overall bioactivity beyond this application remains insufficiently explored. This study investigates the anti-inflammatory properties and underlying mechanisms of T. dubius methanolic extract in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and ICR mice. The methanolic extract of T. dubius inhibited LPS-stimulated inflammatory mediator nitric oxide (NO) without exhibiting cytotoxicity under 1,000 μg/mL. It also decreased the expression of inducible NO synthase (iNOS) and interleukin-6 (IL-6) at both mRNA and protein levels. Additionally, the T. dubius methanolic extract inhibited the phosphorylation of c-Jun N-terminal kinase (JNK) and nuclear factor-kappa B (NF-κB) in LPS-stimulated RAW 264.7 macrophages. Furthermore, T. dubius methanolic extract mitigated weight loss and significantly improved survival rates in the LPS-induced inflammatory animal model. It also reduced the levels of NO and IL-6 in the plasma. Overall, the findings suggest that T. dubius methanolic extract has significant anti-inflammatory properties, primarily through inhibiting the JNK/NF-κB signaling pathway.
목차
Abstract
재료 및 방법
결과 및 고찰
결론
인용문헌
참고문헌 (49)
참고문헌 신청
Kim, M.-J., Kim, M.-J., Kim, K.-B.-W.-R., Park, S.-H., Choi, H.-D., Park, S.-Y., Kim, J.-H., Jang, M.-R., Im, M.-H. and Ahn, D.-H. (2017) Anti-inflammatory effect of Sargassum patens C. Agardh ethanol extract in LPS-induced RAW264.7 cells and mouse ear edema. Microbiology and Biotechnology Letters 45: 110-117.
Brusini, R., Varna, M. and Couvreur, P. (2020) Advanced nanomedicines for the treatment of inflammatory diseases. Advanced Drug Delivery Reviews 157: 161-178.
Kang, B.-K., Kim, M.-J., Kim, K.-B.-W.-R., Ahn, N.-K., Choi, Y.-U., Bark, S.-W., Pak, W.-M., Kim, B.-R., Park, J.-H. and Bae, N.-Y. (2015) The anti-inflammatory effect of skipjack tuna (Katsuwonus pelamis) oil in LPS-induced RAW 264.7 cells and mouse models. Microbiology and Biotechnology Letters 43: 45-55.
Feng, G.-J., Goodridge, H. S., Harnett, M. M., Wei, X.-Q., Nikolaev, A. V., Higson, A. P. and Liew, F.-Y. (1999) Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. The Journal of Immunology 163: 6403-6412.
Tong, W., Chen, X., Song, X., Chen, Y., Jia, R., Zou, Y., Li, L., Yin, L., He, C. and Liang, X. (2020) Resveratrol inhibits LPS-induced inflammation through suppressing the signaling cascades of TLR4-NF-κB/MAPKs/IRF3. Experimental and Therapeutic Medicine 19: 1824-1834.
Brusini, R., Varna, M. and Couvreur, P. (2020) Advanced nanomedicines for the treatment of inflammatory diseases. Advanced Drug Delivery Reviews 157: 161-178.
Kang, B.-K., Kim, M.-J., Kim, K.-B.-W.-R., Ahn, N.-K., Choi, Y.-U., Bark, S.-W., Pak, W.-M., Kim, B.-R., Park, J.-H. and Bae, N.-Y. (2015) The anti-inflammatory effect of skipjack tuna (Katsuwonus pelamis) oil in LPS-induced RAW 264.7 cells and mouse models. Microbiology and Biotechnology Letters 43: 45-55.
Feng, G.-J., Goodridge, H. S., Harnett, M. M., Wei, X.-Q., Nikolaev, A. V., Higson, A. P. and Liew, F.-Y. (1999) Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase. The Journal of Immunology 163: 6403-6412.
Tong, W., Chen, X., Song, X., Chen, Y., Jia, R., Zou, Y., Li, L., Yin, L., He, C. and Liang, X. (2020) Resveratrol inhibits LPS-induced inflammation through suppressing the signaling cascades of TLR4-NF-κB/MAPKs/IRF3. Experimental and Therapeutic Medicine 19: 1824-1834.
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