지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.12
- 수록면
- 221 - 228 (8page)
- DOI
- 10.22889/KJP.2024.55.4.221
이용수
초록· 키워드
오류제보하기
The discovery and application of new substances that can regulate and reduce platelet activation are important for the prevention and treatment of cardiovascular diseases. Previous studies have shown that dioscin inhibits the growth of tumor-related cells and induces apoptosis. In addition, although there have been a few reports on the antiplatelet effect of dioscin, there has been no study that elucidated the mechanism of platelet activation using human platelets. Therefore, in this study, we confirmed whether dioscin has an antithrombotic effect by regulating the activation of human platelets. Dioscin increased cAMP and cGMP in human platelets, preventing Ca<sup>2+</sup> mobilization by inducing IP₃R phosphorylation, and inhibited the binding between integrin αIIb/β₃ and fibrinogen by inducing VASP phosphorylation. Finally, dioscin was shown to significantly inhibit thrombin-induced fibrin thrombus formation. Therefore, dioscin has been shown to possess antiplatelet effects that can slow or halt thrombus formation by regulating the phosphorylation of various signaling molecules and related proteins.
목차
Abstract
재료 및 방법
결과 및 고찰
결론
인용문헌
참고문헌 (32)
참고문헌 신청
Jackson, S. P. (2011) Arterial thrombosis-insidious, unpredictable and deadly. Nat. Med. 17: 1423-1436.
Schwartz, S. M., Heimark, R. L. and Majesky, M. W. (1990) Developmental mechanisms underlying pathology of arteries. Physiol. Rev. 70: 1177-1209.
Payrastre, B., Missy, K., Trumel, C., Bodin, S. and Plantavid, M. and Chap, H. (2000) The integrin alpha IIb/beta 3 in human platelet signal transduction. Biochem. Pharmacol. 60: 1069-1074.
Jennings, L. K. (2009) Role of platelets in atherothrombosis. Am. J. Cardiol. 103: 4A-10A.
Morello, F., Perino, A. and Hirsch, E. (2009) Phosphoinositide 3-kinase signalling in the vascular system. Cardiovasc Res 82: 261-271.
Schwartz, S. M., Heimark, R. L. and Majesky, M. W. (1990) Developmental mechanisms underlying pathology of arteries. Physiol. Rev. 70: 1177-1209.
Payrastre, B., Missy, K., Trumel, C., Bodin, S. and Plantavid, M. and Chap, H. (2000) The integrin alpha IIb/beta 3 in human platelet signal transduction. Biochem. Pharmacol. 60: 1069-1074.
Jennings, L. K. (2009) Role of platelets in atherothrombosis. Am. J. Cardiol. 103: 4A-10A.
Morello, F., Perino, A. and Hirsch, E. (2009) Phosphoinositide 3-kinase signalling in the vascular system. Cardiovasc Res 82: 261-271.
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Anti-platelet Effects of Artemisinin through Regulation of Cyclic Nucleotide on Collagen-induced human Platelets
대한의생명과학회지
2024 .09
-
Anti-platelet effects of Artesunate through Regulation of Cyclic Nucleotide on Collagen-induced Human Platelets
대한의생명과학회지
2023 .03
-
Pathophysiologic and Therapeutic Perspectives Based on Thrombus Histology in Stroke
대한뇌졸중학회지
2020 .01
-
Manual Thrombus Density Measurement Depends on the Method of Thrombus Delineation
대한뇌졸중학회지
2018 .01
-
Shape and Mobility of a Left Ventricular Thrombus Are Predictors of Thrombus Resolution
Korean Circulation Journal
2019 .01
-
Traditional Thrombus Composition and Related Endovascular Outcomes: Catching up with the Recent Evidence
Neurointervention
2024 .07
-
Thrombus Formation Inhibition of Esculetin through Regulation of Cyclic Nucleotides on Collagen-Induced Platelets
대한의생명과학회지
2021 .12
-
Computed Tomography-Based Thrombus Imaging for the Prediction of Recanalization after Reperfusion Therapy in Stroke
대한뇌졸중학회지
2017 .01
-
Association between Fibrinogen and Carotid Atherosclerosis According to Smoking Status in a Korean Male Population
Yonsei Medical Journal
2015 .01
-
The Fibrinogen to Mean Platelet Volume Ratio Can Predict Overall Survival of Patients with Non-Metastatic Gastric Cancer
Journal of Gastric Cancer
2018 .12
-
Direct Thrombus Imaging in Stroke
대한뇌졸중학회지
2016 .01
-
Fibrinogen: Is It Useful as a Predictor for the Initiation of Massive Transfusion?
대한외과학회 학술대회 초록집
2018 .11
-
Right Ventricular Mass: Thrombus or Tumor?
Cardiovascular Imaging Asia
2023 .01
-
알츠하이머병과 경도인지장애에서의 혈장 섬유소원과 C 반응 단백의 농도
노인정신의학
2019 .01
-
Technical Considerations for surgical resection of Renal Cell Carcinoma with IVC thrombus (grade 4) extending to right atrium – Case report
대한임상종양학회 학술대회지
2021 .06
-
Is It Enough to Administer A Single Dose of Fibrinogen Concentration in Massive Traumatic Hemorrhage?
대한외과학회 학술대회 초록집
2021 .11
-
Acute Right Intracardiac Thrombus-in-Transit Complicated by Submassive Pulmonary Embolism
Cardiovascular Imaging Asia
2021 .01
-
Change in fibrinogen levels and severe postoperative bleeding in cardiac surgery
International Journal of Oral Biology
2020 .01
-
Impact of Left Atrial or Left Atrial Appendage Thrombus on Stroke Outcome: A Matched Control Analysis
대한뇌졸중학회지
2023 .01
-
Neutrophil Lymphocyte Ratio as a Predictor of Left Ventricular Apical Thrombus in Patients with Myocardial Infarction
Korean Circulation Journal
2016 .01
이 논문과 함께 이용한 논문
Alkaloids with Acetylcholinesterase Inhibitory Activities from Crinum latifolium L.
Vu Thi T
,
ang
,
Pham Van Cong
외 7명
Natural Product Sciences
2024
.12
테트라트리코펩타이드 반복 도메인 단백질: 구조, 기능 및 생물학적 중요성
최정민
생명과학회지
2025
.04
RWD/RWE 외부대조군 활용 동향 및 시사점
최남경
KPBMA FOCUS
2025
.01
대식세포에서 다래 벌화분에 의한 염증 저해 효과 및 면역 단백질 발현
김성국
,
이문선
,
문시원
외 3명
Journal of Apiculture
2024
.09
새로 개발된 혈전제거술용 혈전 흡입기구의 유용성
전수환
,
김진우
,
김다희
외 4명
대한인터벤션영상기술학회지
2024
.05
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-092171464