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논문 기본 정보

자료유형
학술저널
저자정보
장원재 (인제대학교 의과대학 일산백병원 정신건강의학교실)
저널정보
대한노인정신의학회 노인정신의학 노인정신의학 제23권 제2호
발행연도
2019.1
수록면
45 - 50 (6page)

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초록· 키워드

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Objective:The aim of this study was to measure and compare the levels of fibrinogen and C-reactive protein (CRP) in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) groups and to investigate the correlations between bloodbased inflammatory factors and cognitive functions. Methods:Seventy one subjects participated in this study [AD : 28, MCI : 23, normal control (NC) : 20]. The overall cognitive function of the subjects and the severity of the disease stage were assessed using Mini-Mental Status Examination in the Korean Version of the the CERAD Assessment Packet (MMSE-KC), Global Deterioration Scale (GDS), Clinical Dementia Rating (CDR), Korean neuropsychiatric inventory (K-NPI) and Geriatric Depression Scale (K-GDS). Plasma fibrinogen and CRP were also measured in AD, MCI, and NC groups. Results:Fibrinogen and CRP levels were not significantly different among AD, MCI, and NC groups. Fibrinogen and CRP did not show a significant correlation with MMSE-KC, CDR, GDS, K-NPI and K-GDS scores. Conclusion:In this study, it was found that plasma fibrinogen and CRP did not increase as cognitive function decreased. But this study was the first meaningful study in Korea about the relationship between cognitive impairment and plasma fibrinogen and CRP levels. It is necessary to conduct prospective cohort studies on more patients in the future.

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