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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.6
- 수록면
- 143 - 147 (5page)
- DOI
- 10.5145/ACM.2024.27.2.8
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초록· 키워드
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During nationwide Fantimicrobial surveillance (Korea Global Antimicrobial ResistanceSurveillance System [Kor-GLASS]), the recent emergence of non-oxacillinase (OXA)-23 production by carbapenem-resistant Acinetobacter baumannii (CRAB) isolates wasnoted. In this study, we evaluated resistance mechanisms other than OXA-23 productionto elucidate the shift in considerable CRAB clones. The presence of OXA carbapenemasegenes, such as blaOXA-23, blaOXA-24, blaOXA-58, and blaOXA-51-ISAba1, was determined by PCR.
Other carbapenemase genes, such as blaIMP, blaVIM, blaNDM, blaKPC, blaGES, and blaOXA-48, weredetermined using sequencing. Strains lacking carbapenemase genes were subjected towhole genome sequencing, and resistance genes were analyzed using ResFinder. Four CRABstrains were collected through a Kor-GLASS study in 2022, in which OXA-23 production wasnot identified. The carbapenemase genotypes of the four CRAB strains lacking blaOXA-23 werebla OXA-51-ISAba1, blaOXA-66/ACD25, blaOXA-182, and blaNDM-1. To the best of our knowledge, this is thefirst study to identify CRAB producing New Delhi metallo-β-lactamase (NDM)-1 in Korea. Inconclusion, domestic CRAB resistance mechanisms may undergo subtle changes. Continuousobservations are required to monitor the emergence of new clones.
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