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논문 기본 정보

자료유형
학술저널
저자정보
Park So-Young (Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.Division of Pulmonary, Allergy and Critical Care Medicine, Chung-Ang University Gwangmyeong Hospital,) Lee Sun-Kyung (Department of Mathematics, College of Natural Sciences, Hanyang University, Seoul, Korea.Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University Colle) Song Woo-Jung (Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Kim Min-Hye (Division of Allergy and Clinical Immunology, Department of Internal Medicine, Ewha University Seoul Hospital, Seoul, Korea.) Ban Ga-Young (Department of Pulmonary, Allergy and Critical Care Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea) Kim Joo-Hee (Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.) Kim Byung-Keun (Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.) Kwon Jae-Woo (Department of Allergy and Clinical Immunology, Kangwon National University School of Medicine, Chuncheon, Korea.) Sohn Kyoung-Hee (Division of Pulmonology and Allergy, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.) Lee Hwa Young (Department of Internal Medicine, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.) Jung Jae-Woo (Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.) Park Chan Sun (Department of Internal Medicine, Inje University of College of Medicine, Haeundae Paik Hospital, Busan, Korea.) Kang Sung-Yoon (Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.) Yang Min-Suk (Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea.) Lee Jae-Hyun (Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.) Jang An-Soo (Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.) Kim So Ri (Division of Respiratory Medicine and Allergy, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.) Lee Taehoon (Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea.) 이진국 (가톨릭대학교) 박흥우 (서울대학교병원) Kim Sang Hoon (Department of Internal Medicine, Nowon Eulji Hospital, Eulji University School of Medicine, Seoul, Korea.) 장윤석 (Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.) Koh Young-Il (Department of Allergy and Clinical Immunology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.) Lee Byung-Jae (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) 박해심 (Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.) Kim Sang-Heon (Division of Pulmonary Medicine and Allergy, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.) Cho You Sook (Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research AAIR Vol.16 No.3
발행연도
2024.5
수록면
253 - 266 (14page)
DOI
10.4168/aair.2024.16.3.253

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초록· 키워드

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Purpose: Severe asthma is associated with high morbidity and healthcare utilization; however, treatment options for these patients are limited. This study aimed to determine the therapeutic effects of biologics in clinical practice. Methods: This multicenter, retrospective cohort study included 136 patients who received biologics for at least 4 months between September 2017 and July 2022 at 25 medical centers affiliated with the Korean Severe Asthma Registry (KoSAR). The study evaluated the treatment effects, including acute exacerbation rates, maintenance of oral corticosteroid dosages, lung function, quality of life, blood eosinophil count, and fractional exhaled nitric oxide (FeNO) levels, by comparing measurements before and after 4 months of biologic treatment. Responses for each medication was evaluated based on the Global Evaluation of Treatment Effectiveness score, and any adverse reactions were summarized. Results: With the administration of biologics over the course of 4 months, there was a reduction in asthma acute exacerbations, a significant improvement in lung function, and a significant decrease in daily maintenance dose of oral steroid. Blood eosinophil counts decreased in the mepolizumab and reslizumab groups, while FeNO levels decreased only in the dupilumab group. The Asthma Control Test, Quality of Life Questionnaire for Adult Korean Asthmatics, and the EuroQol-visual analogue scale scores showed a significant improvement. Most patients (80.15%) responded to the biologic treatment. Meanwhile, non-responders often had chronic rhinosinusitis as a comorbidity, exhibited lower lung function, and required higher doses of oral steroids. No severe adverse events were reported. Conclusions: Biologics are highly effective in Korean patients with Type 2 severe asthma, significantly reducing acute exacerbation rates and doses of oral corticosteroids, while also improving lung function. Therefore, it seems beneficial to administer biologics without any restrictions to patients exhibiting Type 2 severe asthma.
#Asthma #eosinophils #lung function #rhinosinusitis #mepolizumab #reslizumab #dupilumab #omalizumab

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