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논문 기본 정보

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학술저널
저자정보
Sugihara Nao (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Okada Yoshikiyo (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Tomioka Akira (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Ito Suguru (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Tanemoto Rina (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Nishii Shin (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Mizoguchi Akinori (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Inaba Kenichi (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Hanawa Yoshinori (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Horiuchi Kazuki (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Wada Akinori (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Akita Yoshihiro (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Higashiyama Masaaki (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Kurihara Chie (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Komoto Shunsuke (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Tomita Kengo (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan) Hokari Ryota (Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver Vol.18 No.3
발행연도
2024.5
수록면
465 - 475 (11page)
DOI
10.5009/gnl220100

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Background/Aims: Recent studies indicate that probiotics, which have attracted attention as a treatment for irritable bowel syndrome, affect intestinal homeostasis. In this study, we investigated whether Zygosaccharomyces sapae (strain I-6), a probiotic yeast isolated from miso (a traditional Japanese fermented food), could improve irritable bowel syndrome symptoms. Methods: Male Wistar rats were exposed to water avoidance stress (WAS). The number of defecations during WAS and the visceral hypersensitivity before and after WAS were evaluated using colorectal distension. Tight junction changes were assessed by Western blotting. Some rats were fed with strain I-6 or β-glucan from strain I-6. Changes in the intestinal microbiota were analyzed. The effect of fecal microbiota transplantation after WAS was evaluated similarly. Caco-2 cells were stimulated with interleukin-1β and tight junction changes were investigated after coculture with strain I-6. Results: The increased number of stool pellets and visceral hypersensitivity induced by WAS were suppressed by administering strain I-6. The decrease in tight junction protein occludin by WAS was reversed by the administration of strain I-6. β-Glucan from strain I-6 also suppressed those changes induced by WAS. In the rat intestinal microbiota, treatment with strain I-6 altered the β-diversity and induced changes in bacterial occupancy. Upon fecal microbiota transplantation, some symptoms caused by WAS were ameliorated. Conclusions: These results suggest that traditional fermented foods such as miso in Japan are valuable sources of probiotic yeast candidates, which may be useful for preventing and treating stress-induced visceral hypersensitivity.
#Irritable bowel syndrome #Yeasts #Fermented foods #Tight junction proteins #Gut microbiota

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