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논문 기본 정보

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학술저널
저자정보
Nam-Hee Kim (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea) Hye Sun Choi (National Institute of Crop Science, Rural Development Administration, Suwon, Gyeonggi-do, Korea) Moon Young Lee (Digestive Diseases Research Institute, School of Medicine, Wonkwang University, Iksan, Jeollabuk-do, Korea) Hyunbin Seong (Department of Food Science and Technology, Chungbuk National University, Cheongju, Chungcheongbuk-do, Korea) Nam Soo Han (Department of Food Science and Technology, Chungbuk National University, Cheongju, Chungcheongbuk-do, Korea) Hae-Jin Hu (Endomics, Inc, Seongnam, Gyeonggi-do, Korea; and 6Gut & Food Healthcare Co, Ltd, Seongnam, Gyeonggi-do, Korea) Yong Sung Kim (Digestive Diseases Research Institute, School of Medicine, Wonkwang University, Iksan, Jeollabuk-do, Korea) Jung Ho Park (Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.30 No.2
발행연도
2024.4
수록면
194 - 207 (14page)
DOI
10.5056/jnm23184

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Background/AimsThis study aims to investigate the effect of a fermented rice drink with Lactiplantibacillus plantarum JSA22 on symptoms, blood tests, microbiomes, and fecal metabolites in patients with irritable bowel syndrome (IBS) who were overweight. MethodsSixty overweight (body mass index ≥ 23 kg/m2) patients aged between 20 and 65 with IBS were enrolled. Patients were divided into 2 groups and administered either a fermented rice drink or an nonfermented rice drink for a month. The symptom questionnaire, blood samples, and stool samples for microbiome and metabolite were collected before and after the month of rice drink administration. The primary efficacy variable was the subject’s global assessment of IBS symptoms. ResultsIn both groups, global IBS symptoms, including abdominal pain, bowel habit, urgency, and abdominal distension, improved significantly (P < 0.01). The abdominal bloating was more significantly improved in the fermented rice drink group than in the nonfermented rice drink group (P < 0.05). Significant changes were not observed in metabolic syndrome-related blood tests or fecal metabolites in either group. However, microbiome analysis showed significant differences in genus levels before and after consuming fermented rice drink, such as in Blautia in stool (P = 0.020) and Prevotella (P = 0.017) and Oribacterium (P = 0.018) in saliva. ConclusionsThe fermented rice drink with L. plantarum JSA22 showed a beneficial effect in reducing abdominal distension in IBS patients. Bacteria that reduce visceral fat accumulation increased in the stool and saliva of patients who consumed fermented rice drinks.

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