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논문 기본 정보

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학술저널
저자정보
Robert L Burr (Department of Biobehavioral Nursing and Health Informatics University of Washington Seattle WA USA) Haiwei Gu (Northwest Metabolomics Research Center Department of Anesthesiology and Pain Medicine University of) Kevin Cain (Office for Nursing Research University of Washington Seattle WA USA) Danijel Djukovic (Northwest Metabolomics Research Center Department of Anesthesiology and Pain Medicine University of) Xinyu Zhang (Northwest Metabolomics Research Center Department of Anesthesiology and Pain Medicine University of) Claire Han (Department of Biobehavioral Nursing and Health Informatics University of Washington Seattle WA USA) Nini Callan (Helfgott Research Institute National University of Natural Medicine Portland OR USA) Daniel Raftery (Northwest Metabolomics Research Center Department of Anesthesiology and Pain Medicine University of) Margaret Heitkemper (Department of Biobehavioral Nursing and Health Informatics University of Washington Seattle WA USA)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.25 No.4
발행연도
2019.1
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551 - 562 (12page)

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Background/Aims Patients with irritable bowel syndrome (IBS) often report poor sleep quality. Whether poor sleep is associated with tryptophan (Trp) metabolites is unknown. We compared serum Trp metabolites in women with IBS and healthy controls (HCs) using targeted liquid chromatography mass spectrometry (LC-MS)-based profiling. In IBS only, we explored whether Trp metabolites are associated with IBS symptoms and subjective and objective sleep indices, serum cortisol, plasma adrenocorticotropic hormone (ACTH), and cortisol/ACTH levels. Methods Blood samples were obtained every 80 minutes in 21 HCs and 38 IBS subjects following an anticipation-of-public-speaking stressor during a sleep laboratory protocol. Subjects completed symptom diaries for 28 days. Adjacent values of metabolites were averaged to represent 4 time-periods: awake, early sleep, mid-sleep, and mid-to-late sleep. Thirteen of 20 targeted Trp metabolites were identified. Results Ten of 13 Trp metabolites decreased across the night, while nicotinamide increased in both groups. A MANOVA omnibus test performed after principal component analysis showed a significant difference in these 13 principal component (P = 0.014) between groups. Compared to HCs, nicotinamide levels were higher and indole-3-lactic acid levels lower in the IBS group. Melatonin and indole-3-acetic acid levels were associated with several subjective/objective sleep measures; decreased stool consistency/frequency and abdominal pain were positively associated with melatonin and serotonin in the IBS group. The kynurenine and kynurenic acid were associated with ACTH (positively) and cortisol/ACTH (negatively). Conclusions Nighttime Trp metabolites may provide clues to poor sleep and stress with IBS. Further study of the mechanism of metabolite action is warranted.
#Irritable bowel syndrome #Melatonin #Sleep #Tryptophan

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참고문헌 (46)

참고문헌 신청
Chang L / 2018 / Functional bowel disorders : a roadmap to guide the next generation of research / Gastroenterology 154:723~735 google schola Fass R / 2000 / Sleep disturbances in clinic patients with functional bowel disorders / Am J Gastroenterol 95:1195~2000 google schola Jarrett M / 2000 / Sleep disturbance influences gastrointestinal symptoms in women with irritable bowel syndrome / Dig Dis Sci 45:952~959 google schola Burr RL / 2009 / Catecholamine and cortisol levels during sleep in women with irritable bowel syndrome / Neurogastroenterol Motil 21:1148~e97 google schola Heitkemper MM / 2012 / Anticipation of public speaking and sleep and the hypothalamic-pituitary-adrenal axis in women with irritable bowel syndrome / Neurogastroenterol Motil 24:626~631 google schola

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