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논문 기본 정보

자료유형
학술저널
저자정보
Liu Peng-Cheng (Department of Rheumatology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.) Peng Yi-Lin (Department of Rheumatology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.) Li Jian-Bin (Department of Rheumatology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.) Lv Meng-Na (The First Clinical Medical College of Nanchang University, Nanchang, China.) Yu Shu-Jiao (Department of Rheumatology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.) Wu Rui (Department of Rheumatology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.)
저널정보
대한피부과학회 Annals of Dermatology Annals of Dermatology Vol.36 No.3
발행연도
2024.6
수록면
163 - 171 (9page)
DOI
10.5021/ad.23.126

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Background: A higher incidence of herpes zoster (HZ) was found in people with decreased cell-mediated immunity. However, the relationship between cellular immunity and HZ infec- tion in patients with autoimmune inflammator y rheumatic diseases (AIRD) remains elusive. Objective: To investigate the role of CD4/CD8 ratio in patients with AIRD and HZ. Methods: This case-control study compared AIRD patients with and without HZ. We chose 70 AIRD patients with HZ as the experimental group and 140 AIRD patients without HZ as the control group. The clinical and laborator y findings were assessed in each trial participant. Results: The CD4/CD8 ratio (odds ratio [OR], 0.22; 95% confidence inter val [CI], 0.10–0.49) was independently associated with the occurrence of HZ after adjusting for various confounders. Nonlinear analysis has unveiled a more profound nonlinear relationship between the CD4/CD8 ratio and the occurrence of HZ in patients with AIRD. The OR of HZ increased with a decreasing CD4/CD8 ratio before the turning point of 2. The adjusted regression coefficient was 0.14 (95% CI, 0.05–0.37, p<0.0001) for CD4/CD8 ratio less than 2. Conclusion: The CD4/CD8 ratio was expected to be a ver y promising quantitative biomarker for predicting the risk of developing HZ in patients with AIRD.

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