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논문 기본 정보

자료유형
학술저널
저자정보
Lee Ji-seon (College of Medicine, CHA University, Pocheon, Korea.) Heo Do-yun (College of Medicine, Hanyang University, Seoul, Korea.) Choi Kyung-Hae (Department of Neurology, Hanyang University Hospital, College of Medicine, Hanyang University, Seoul, Korea.) Kim Hee-Jin (Department of Neurology, Hanyang University Hospital, College of Medicine, Hanyang University, Seoul, Korea.)
저널정보
대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제23권 제2호
발행연도
2024.4
수록면
95 - 106 (12page)
DOI
10.12779/dnd.2024.23.2.95

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Background and Purpose: Ventricle enlargement has been implicated in the pathophysiology of Alzheimer’s disease (AD). We studied the relationship between ventricular size and cognitive function in patients with AD. We focused on the effect of the initial ventricle size on the rate of cognitive decline in patients with AD. Methods: A retrospective analysis of probable clinical AD participants with more than 2 magnetic resonance imaging images was performed. To measure ventricle size, we used visual rating scales of (1) Cardiovascular Health Study (CHS) score and (2) conventional linear measurement method. Results: Increased clinical dementia rating (CDR) was correlated with a decreased Mini-Mental Status Examination (MMSE) score, and increased medial temporal lobe atrophy (MTLA) and global ventricle size (p<0.001, p<0.001, p=0.021, respectively). There was a significant correlation between the change in cognitive function in the group (70%–100%ile) with a large initial ventricle size (p=0.021 for ΔCDR, p=0.01 for ΔMMSE), while the median ventricle size (30%–70%ile) showed correlation with other brain structural changes (MTLA, frontal atrophy [FA], and white matter) (p=0.036 for initial MTLA, p=0.034 for FA). Conclusions: In this study, the initial ventricle size may be a potential new imaging biomarker for initial cognitive function and clinical progression in AD. We found a relationship between the initial ventricle size and initial AD-related brain structural biomarkers.

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