지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.5
- 수록면
- 250 - 255 (6page)
- DOI
- https://doi.org/10.5483/BMBRep.2023-0174
이용수
초록· 키워드
오류제보하기
Due to their stem-like characteristics and immunosuppressiveproperties, Mesenchymal stem cells (MSCs) offer remarkable potential in regenerative medicine. Much effort has been devotedto enhancing the efficacy of MSC therapy by enhancing MSCmigration. In this study, we identified deubiquitinase BRCA1-associated protein 1 (BAP1) as an inhibitor of MSC migration.
Using deubiquitinase siRNA library screening based on an invitro wound healing assay, we found that silencing BAP1 significantly augmented MSC migration. Conversely, BAP1 overexpression reduced the migration and invasion capabilities ofMSCs. BAP1 depletion in MSCs upregulates ERK phosphorylation, thereby increasing the expression of the migration factor,osteopontin. Further examination revealed that BAP1 interactswith phosphorylated ERK1/2, deubiquitinating their ubiquitins,and thus attenuating the ERK signaling pathway. Overall, ourstudy highlights the critical role of BAP1 in regulating MSC migration through its deubiquitinase activity, and suggests a novelapproach to improve the therapeutic potential of MSCs in regenerative medicine.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
BAP1 as a guardian of genome stability: implications in human cancer
Experimental and Molecular Medicine
2023 .04
-
Three-Dimensional Culture of Mesenchymal Stem Cells
조직공학과 재생의학
2015 .01
-
Mitochondrial genome mutations in mesenchymal stem cells derived from human dental induced pluripotent stem cells
BMB Reports
2019 .01
-
Superoxide dismutase 3 protects mesenchymal stem cells through enhanced autophagy and regulation of FoxO3a trafficking
BMB Reports
2018 .01
-
Immunomodulatory effect of mesenchymal stem cells and mesenchymal stem-cell-derived exosomes for COVID-19 treatment
BMB Reports
2020 .01
-
Atorvastatin Pretreatment Ameliorates Mesenchymal Stem Cell Migration through miR-146a/CXCR4 Signaling
조직공학과 재생의학
2021 .10
-
Mesenchymal Stem Cell Spheroids: A Promising Tool for Vascularized Tissue Regeneration
조직공학과 재생의학
2024 .07
-
전기 자극을 이용한 CD271 양성 중간엽줄기세포의 연골세포 분화능
KSBB Journal
2021 .03
-
Erythropoietin-Modified Mesenchymal Stem Cells Enhance Anti-fibrosis Efficacy in Mouse Liver Fibrosis Model
조직공학과 재생의학
2020 .01
-
The Therapeutic Potential of Extracellular Vesicles Versus Mesenchymal Stem Cells in Liver Damage
조직공학과 재생의학
2020 .01
-
MMP13-Overexpressing Mesenchymal Stem Cells Enhance Bone Tissue Formation in the Presence of Collagen Hydrogel
조직공학과 재생의학
2023 .06
-
Donor-dependent variation of human umbilical cord blood mesenchymal stem cells in response to hypoxic preconditioning and amelioration of limb ischemia
Experimental and Molecular Medicine
2018 .01
-
회귀분석을 통한 토양 내 Pyr 농도로부터 BaP와 총 PAH의 예측기법
대한환경공학회지
2017 .03
-
Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases
Experimental and Molecular Medicine
2017 .01
-
Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Management of COVID19-Associated Lung Injury: A Review on Publications, Clinical Trials and Patent Landscape
조직공학과 재생의학
2022 .08
-
Chemokine Receptors Expression in MSCs: Comparative Analysis in Diff erent Sources and Passages
조직공학과 재생의학
2017 .01
-
윤활유첨가제로써 마모억제 성능을 갖는 Dimethacryloyloxy Alkane 유도체에 관한 연구
공업화학
2016 .01
-
Adipokines at the crossroads of obesity and mesenchymal stem cell therapy
Experimental and Molecular Medicine
2023 .02
-
Extracellular vesicles from pluripotent stem cell-derived mesenchymal stem cells acquire a stromal modulatory proteomic pattern during differentiation
Experimental and Molecular Medicine
2018 .01
-
NMR-based metabolic responses of the zebrafish exposed to Benzo[a]pyrene
Journal of the Korean Magnetic Resonance Society
2022 .12
최근 본 자료
댓글(0)
0