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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 344 - 349 (6page)
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초록· 키워드
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Therapeutic applications of mesenchymal stem cells (MSCs) are limited due to their early death within the first few days of transplantation. Therefore, to improve the efficacy of cellbased therapies, it is necessary to manipulate MSCs so that they can resist various stresses imposed by the microenvironment. Moreover, the role of superoxide dismutase 3 (SOD3) in regulating such survival under different stress conditions remain elusive. In this study, we overexpressed SOD3 in MSCs (SOD3-MSCs) and evaluated its effect under serum starvation conditions. Nutritional limitation can decrease the survival rate of transplanted MSCs and thus can reduce their efficacy during therapy. Interestingly, we found that SOD3-MSCs exhibited reduced reactive oxygen species levels and greater survival rates than normal MSCs under serum-deprived conditions. In addition, overexpression of SOD3 attenuated starvationinduced apoptosis with increased autophagy in MSCs. Moreover, we have demonstrated that SOD3 protects MSCs against the negative effects of serum deprivation via modulation of AMP-activated protein kinase/sirtulin 1, extracellular signalregulated kinase activation, and promoted Forkhead box O3a trafficking to the nucleus. Taken together, these results demonstrate that SOD3 promotes MSCs survival and add further evidence to the concept that SOD3-MSCs may be a potential therapeutic agent with better outcomes than normal MSCs for various diseases involving oxidative stress and compromised MSCs survival during therapy.
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참고문헌 (40)
참고문헌 신청
Biffi A / 2013 / Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy / Science 341:1233158
Garbern JC / 2013 / Cardiac stem cell therapy and the promise of heart regeneration cell / Stem Cell 12:689~698
Greco SJ / 2012 / Mesenchymal stem cells in drug/gene delivery: implications for cell therapy / TherDeliv 3:997~1004
Law S / 2013 / Mesenchymal stem cell and regenerative medicine: regeneration versus immunomodulatory challenges / Am J Stem Cells 2:22~38
Matthew B Murphy / 2013 / Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine / Experimental and Molecular Medicine 45:1~16
Garbern JC / 2013 / Cardiac stem cell therapy and the promise of heart regeneration cell / Stem Cell 12:689~698
Greco SJ / 2012 / Mesenchymal stem cells in drug/gene delivery: implications for cell therapy / TherDeliv 3:997~1004
Law S / 2013 / Mesenchymal stem cell and regenerative medicine: regeneration versus immunomodulatory challenges / Am J Stem Cells 2:22~38
Matthew B Murphy / 2013 / Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine / Experimental and Molecular Medicine 45:1~16
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