지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.8
- 수록면
- 281 - 293 (13page)
이용수
초록· 키워드
오류제보하기
We previously reported that leukotriene B4 (LTB4) contained in Trichomonas vaginalis-derived secretory products (TvSP) play an essential role in interleukin-8 (IL-8) production in human mast cell line (HMC-1 cells) via LTB4 receptor (BLT)-mediated Nuclear Factor-kappa B (NF-кB) activation. Dynamin, a GTPase, has been known to be involved in endocytosis of receptors for signaling of production of cytokine or chemokines. In the present study, we investigated the role of dynamin-mediated BLT1 endocytosis in TvSP-induced IL-8 production. When HMC-1 cells were transfected with BLT1 or BLT2 siRNA, TvSP-induced IL-8 production was significantly inhibited compared with that in cells transfected with control siRNA. In addition, pretreatment of HMC-1 cells with a dynamin inhibitor (Dynasore) reduced IL-8 production induced by TvSP or LTB₄. TvSP- or LTB₄-induced phosphorylation of NF-кB was also attenuated by pretreatment with Dynasore. After exposing HMC-1 cells to TvSP or LTB₄, BLT1 was translocated from the intracellular compartments to the plasma membrane within 30 min. At 60 min after stimulation with TvSP or LTB₄, BLT1 remigrated from the cell surface to intracellular areas. Pretreatment of HMC-1 cells with dynamin-2 siRNA blocked internalization of BLT1 induced by TvSP or LTB₄. Co-immunoprecipitation experiments revealed that dynamin-2 strongly interacted with BLT1 60 min after stimulation with TvSP or LTB₄. These results suggest that T. vaginalis-secreted LTB4 induces IL-8 production in HMC-1 cells via dynamin 2-mediated endocytosis of BLT1 and phosphorylation of NF-кB.
목차
Abstract
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Activation of MAPK Is Required for ROS Generation and Exocytosis in HMC-1 Cells Induced by Trichomonas vaginalis-Derived Secretory Products
Parasites, Hosts and Diseases
2015 .10
-
CysLT receptor-mediated NOX2 activation is required for IL-8 production in HMC-1 cells induced by Trichomonas vaginalis-derived secretory products
Parasites, Hosts and Diseases
2024 .08
-
Ischemic brain injury decreases dynamin-like protein 1 expression in a middle cerebral artery occlusion animal model and glutamate-exposed HT22 cells
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Outcomes of surgical management of buschke-lowenstein tumor in a Philippine tertiary hospital
Annals of Coloproctology
2022 .02
-
Inflammatory Responses in a Benign Prostatic Hyperplasia Epithelial Cell Line (BPH-1) Infected with Trichomonas vaginalis
Parasites, Hosts and Diseases
2016 .04
-
Proliferation of Mouse Prostate Cancer Cells Inflamed by Trichomonas vaginalis
Parasites, Hosts and Diseases
2021 .12
-
Interaction between Trichomonas vaginalis and the Prostate Epithelium
Parasites, Hosts and Diseases
2017 .04
-
Radical surgical management of perianal giant condyloma acuminatum of Buschke and Löwenstein: long-term results of 11 cases
Annals of Coloproctology
2023 .06
-
Panax ginsengederived fraction BIOGF1K reduces atopic dermatitis responses via suppression of mitogen-activated protein kinase signaling pathway
Journal of Ginseng Research
2020 .05
-
Toll-Like Receptor 7 (TLR7) Mediated Transcriptomic Changes on Human Mast Cells
Annals of Dermatology
2021 .10
-
Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Out-sourcing for Trans-presentation : Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
Immune Network
2018 .02
-
Suppressing NF-κB/Caspase-1 Activation is a Mechanism Involved in the Anti-inflammatory Effect of Rubi Fructus in Stimulated HMC-1 Cells
대한의생명과학회지
2023 .09
-
Trichomonas vaginalis α-Actinin 2 Modulates Host Immune Responses by Inducing Tolerogenic Dendritic Cells via IL-10 Production from Regulatory T Cells
Parasites, Hosts and Diseases
2017 .08
-
Inflammatory response to Trichomonas vaginalis in the pathogenesis of prostatitis and benign prostatic hyperplasia
Parasites, Hosts and Diseases
2023 .02
-
Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist’s Perspective
International Neurourology Journal
2015 .01
-
Interleukin-18 Receptor α Modulates the T Cell Response in Food Allergy
Allergy, Asthma & Immunology Research
2022 .07
-
Prevalence of Trichomoniasis by PCR in Women Attending Health Screening in Korea
Parasites, Hosts and Diseases
2016 .04
-
IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
Immune Network
2020 .02
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-090977566