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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.8
- 수록면
- 202 - 210 (9page)
- DOI
- 10.7783/KJMCS.2024.32.4.202
이용수
초록· 키워드
오류제보하기
Backround: Rosa rugosa Thnub. water extract (WRT) has been used as a folk medicine with various pharmacological properties for a long time in Asia. This study was conducted to evaluate the acute and genetic toxicity of WRT.
Method and Result: No test substance-related deaths, clinical signs, weight changes, or macroscopic manifestations were observed in Sprague-Dawley (SD) rats or Institute of Cancer Research (ICR) mice test animals. WRT did not increase the number of revertant colonies of Salmonella typhimurium or Escherichia coli strains in the presence or absence of metabolic activity. Moreover, it did not induce structurally abnormal chromosomes in Chinese hamster lung (CHL) cells with or without metabolic activity, which did not increase by more than 2-fold compared to that in the negative controls. In the in vivo micronucleus test, WRT did not affect the formation of micronuclei compared with the the negative control.
Conclusion: Acute toxicity test for WRT extract in SD rats did not reveal any clinical signs and weight loss. Ames test, in vitro mammalian chromosomal aberration, and in vivo micronucleus test did not reveal WRT genotoxicityt.
Method and Result: No test substance-related deaths, clinical signs, weight changes, or macroscopic manifestations were observed in Sprague-Dawley (SD) rats or Institute of Cancer Research (ICR) mice test animals. WRT did not increase the number of revertant colonies of Salmonella typhimurium or Escherichia coli strains in the presence or absence of metabolic activity. Moreover, it did not induce structurally abnormal chromosomes in Chinese hamster lung (CHL) cells with or without metabolic activity, which did not increase by more than 2-fold compared to that in the negative controls. In the in vivo micronucleus test, WRT did not affect the formation of micronuclei compared with the the negative control.
Conclusion: Acute toxicity test for WRT extract in SD rats did not reveal any clinical signs and weight loss. Ames test, in vitro mammalian chromosomal aberration, and in vivo micronucleus test did not reveal WRT genotoxicityt.
목차
ABSTRACT
서언
재료 및 방법
결과
고찰
REFERENCES
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