지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.23 No.1
- 발행연도
- 2018.3
- 수록면
- 70 - 76 (7page)
- DOI
- 10.3746/pnf.2018.23.1.70
이용수
초록· 키워드
오류제보하기
Many studies have reported therapeutic efficacy of corn silk extract. However, research on its toxicity and safe dose range is limited. Thus, the objective of this study was to determine the acute and subacute toxicity of corn silk extract in ICR mice. To determine acute toxicity, corn silk extract containing high levels of maysin was orally administered to mice at a dose of 0 or 2,000 mg/kg. Clinical symptoms, mortality, and body weight changes were recorded for 14 days. To determine subacute toxicity, corn silk extract was orally administered to mice over a 4-week period, and then body weight, water and food consumption, and organ weight were determined. In addition, urine and serum analyses were performed. In the acute toxicity study, no death or abnormal symptoms was observed in all treatment groups during the study period. Body weights did not show any significant change compared to those of the control group. Lethal dose of corn silk extract was estimated to be more than 2,000 mg/kg. In the 4-week subacute toxicity study, there was no corn silk extract related toxic effect on body weight, water intake, food consumption, urine parameters, clinical chemistry, or organ weight. Histopathological examination showed no abnormality related to the administration of corn silk extract at 500 mg/kg. The maximum non-toxic dose of corn silk extract containing high levels of maysin was found to be more than 500 mg/kg.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
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[학술지(정기간행물)] - Ernst E / 1998 / Harmless herbs? A review of the recent literature / Am J Med 104 : 170 ~ 178
[학술지(정기간행물)] - Heck AM / 2000 / Potential interactions between alternative therapies and warfarin / Am J Health Syst Pharm 57 : 1221 ~ 1227
[학술지(정기간행물)] - Hasanudin K / 2012 / Corn silk (Stigma maydis) in healthcare: a phytochemical and pharmacological review / Molecules 17 : 9697 ~ 9715
[학술지(정기간행물)] - Fossen T / 2001 / Anthocyanins from maize (Zea mays) and reed canarygrass (Phalaris arundinacea) / J Agric Food Chem 49 : 2318 ~ 2321
[학술지(정기간행물)] - Ernst E / 1998 / Harmless herbs? A review of the recent literature / Am J Med 104 : 170 ~ 178
[학술지(정기간행물)] - Heck AM / 2000 / Potential interactions between alternative therapies and warfarin / Am J Health Syst Pharm 57 : 1221 ~ 1227
[학술지(정기간행물)] - Hasanudin K / 2012 / Corn silk (Stigma maydis) in healthcare: a phytochemical and pharmacological review / Molecules 17 : 9697 ~ 9715
[학술지(정기간행물)] - Fossen T / 2001 / Anthocyanins from maize (Zea mays) and reed canarygrass (Phalaris arundinacea) / J Agric Food Chem 49 : 2318 ~ 2321
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UCI(KEPA) : I410-ECN-0101-2018-594-001907037