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논문 기본 정보

자료유형
학술저널
저자정보
Choi Byungjin (Department of Biomedical Sciences, Ajou University Graduate School of Medicine) Oh Ah Ran (Department of Anesthesiology and Pain Medicine, Samsung Medical Center) 박정찬 (삼성서울병원) 이종환 (성균관대학교) Yang Kwangmo (Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) Lee Dong Yun (Department of Biomedical Sciences, Ajou University Graduate School of Medicine) Rhee Sang Youl (Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine) Kang Sang Soo (Kangdong Sacred Heart Hospital, College of Medicine, Hallym University) Lee Seung Do (Division of Cardiology, Department of Internal Medicine, Gyeongsang National University Hospital) Lee Sun Hack (Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital) Jeong Chang Won (Central Research Center of Biomedical Research Institute, Wonkwang University Hospital) Park Bumhee (Department of Biomedical Sciences, Ajou University Graduate School of Medicine) 설수빈 (아주대학교) Park Rae Woong (독립연구자) Lee Seunghwa (Department of Cardiology, Wiltse Memorial Hospital)
저널정보
대한마취통증의학회(구 대한마취과학회) Korean Journal of Anesthesiology Korean Journal of Anesthesiology Vol.77 No.1
발행연도
2024.2
수록면
66 - 76 (11page)
DOI
10.4097/kja.23043

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Background: Perioperative adverse cardiac events (PACE), a composite of myocardial infarction, coronary revascularization, congestive heart failure, arrhythmic attack, acute pulmonary embolism, cardiac arrest, and stroke during 30-day postoperative period, is associated with long-term mortality, but with limited clinical evidence. We compared long-term mortality with PACE using data from nationwide multicenter electronic health records.Methods: Data from 7 hospitals, converted to Observational Medical Outcomes Partnership Common Data Model, were used. We extracted records of 277,787 adult patients over 18 years old undergoing non-cardiac surgery for the first time at the hospital and had medical records for more than 180 days before surgery. We performed propensity score matching and then an aggregated meta‑analysis.Results: After 1:4 propensity score matching, 7,970 patients with PACE and 28,807 patients without PACE were matched. The meta‑analysis showed that PACE was associated with higher one-year mortality risk (hazard ratio [HR]: 1.33, 95% CI [1.10, 1.60], P = 0.005) and higher three-year mortality (HR: 1.18, 95% CI [1.01, 1.38], P = 0.038). In subgroup analysis, the risk of one-year mortality by PACE became greater with higher-risk surgical procedures (HR: 1.20, 95% CI [1.04, 1.39], P = 0.020 for low-risk surgery; HR: 1.69, 95% CI [1.45, 1.96], P < 0.001 for intermediate-risk; and HR: 2.38, 95% CI [1.47, 3.86], P = 0.034 for high-risk).Conclusions: A nationwide multicenter study showed that PACE was significantly associated with increased one-year mortality. This association was stronger in high-risk surgery, older, male, and chronic kidney disease subgroups. Further studies to improve mortality associated with PACE are needed.

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