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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.11
- 수록면
- 359 - 366 (8page)
- DOI
- 10.17519/apiculture.2023.11.38.4.359
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초록· 키워드
오류제보하기
We recently reported that the ethanol extracts of Korean propolis (EEKP) possesses antiangiogenic activity both in vitro and in vivo. However, the mechanism of angiogenesis inhibition by Korean propolis have not been fully elucidated. In this study, we investigated the antiangiogenic effects of EEKP on tube-forming human umbilical vein endothelial cells (HUVECs). We found that inhibition of tube formation by EEKP was accompanied by partial fragmentation of endothelial cells, indicating that it induced cell death. Western blotting revealed that EEKP induced inactivation of Raf/MEK/ERK pathway in a concentration-dependent manner. EEKP also induced up regulation of p38 MAPK. It was shown that EEKP induced apoptosis via activation of pro-apoptotic signaling such as caspase cascades. Furthermore, EEKP induced the reduction of vascular endothelial cadherin (VE-cadherin) and platelet endothelial cell adhesion molecule-1 (PECAM-1). These results indicate that EEKP exerts its antiangiogenic effects through induction of HUVECs apoptosis. Korean propolis may have the potential to be developed into pharmaceutical drugs for the treatment of angiogenesis-dependent human diseases such as cancer.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
CONCLUSION
LITERATURE CITED
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UCI(KEPA) : I410-151-24-02-088512701