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자료유형
학술저널
저자정보
Kim Jae-Yoon (Department of Surgery Seoul National University College of Medicine Seoul Korea) 이남준 (서울대학교) Kim Yoon Jun (Department of Internal Medicine Seoul National University College of Medicine Seoul Korea) Chie Eui Kyu (Department of Radiation Oncology Seoul National University College of Medicine Seoul Korea) Kim Jiyoung (Department of Surgery Seoul National University College of Medicine Seoul Korea) Choi Hyun Hwa (Department of Surgery Seoul National University College of Medicine Seoul Korea) Lee Jaewon (Department of Surgery Seoul National University College of Medicine Seoul Korea) Lee Sola (Department of Surgery Seoul National University College of Medicine Seoul Korea) Hong Su Young (Department of Surgery Seoul National University College of Medicine Seoul Korea) Lee Jeong-Moo (Department of Surgery Seoul National University College of Medicine Seoul Korea) Hong Suk Kyun (Department of Surgery Seoul National University College of Medicine Seoul Korea) Choi YoungRok (Department of Surgery Seoul National University College of Medicine Seoul Korea) Lee Kwang-Woong (Department of Surgery Seoul National University College of Medicine Seoul Korea) Suh Kyung-Suk (Department of Surgery Seoul National University College of Medicine Seoul Korea)
저널정보
대한이식학회 Clinical Transplantation and Research Korean Journal of Transplantation Vol.37 No.1
발행연도
2023.3
수록면
69 - 75 (7page)
DOI
10.4285/kjt.22.0054

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Adrenal and spinal metastases of hepatocellular carcinoma (HCC) are rare entities with significant morbidity and mortality, particularly after liver transplantation (LT). We report a case of a 49-year-old man who underwent LT for hepatitis B-related end-stage liver disease and HCC (single 4.5 cm lesion [T1N0], without vascular invasion) in 2016. Eighteen months later, adrenal metastasis and hepatitis B seropositive conversion were developed with normal serum tumor. Adrenal metastasis was treated with radiation therapy (RT) and hepatitis B showed spontaneous seronegative conversion. However, 35 months later, spinal metastasis occurred with elevation of the protein induced by vitamin K absence or antagonist-II (PIVKA-II) level (197 mAU/mL), along with hepatitis B seropositive conversion. After sorafenib, sequential regorafenib with RT led to partial response of the spinal lesions, along with hepatitis B seronegative conversion and normal PIVKA-II levels. After 9 months of regorafenib combined with RT, two recurrent lesions were found, as well as hepatitis B seropositive conversion and lesions were treated with transarterial chemoembolization. The patient survived for more than 71 months after LT and 53 months after recurrence under various combinations of therapy. Combined systemic and locoregional therapies can be a treatment option for HCC recurrence, even in LT patients.

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