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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 84 - 89 (6page)
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The efficacy and safety of sequential systemic therapy for the treatment of recurrent hepatocellular carcinoma (HCC) after liver transplantation (LT) are not well established. This study describes a successful experience where sequential therapy with sorafenib followed by regorafenib was used to treat recurrent HCC in a 54-year old male LT recipient. After HCC recurred in both lungs 10 months after LT, sorafenib was administered with radiation therapy to treat pulmonary metastases. However, after 4 months of sorafenib treatment showed progressive pulmonary metastases, sequential regorafenib treatment was started. After 3 months (cycles) of regorafenib treatment, tumor response was partial, and after 6 months (cycles), disease status remained stable without signs of progression or drug-related serious adverse events. This case suggests that sequential systemic therapy is feasible in patient with recurrent HCC after LT.
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참고문헌 (18)
참고문헌 신청
Sapisochin G / 2017 / Liver transplantation for hepatocellular carcinoma : outcomes and novel surgical approaches / Nat Rev Gastroenterol Hepatol 14:203~217
Mazzaferro V / 1996 / Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis / N Engl J Med 334:693~699
Yao FY / 2007 / Liver transplantation for hepatocellular carcinoma : validation of the UCSF-expanded criteria based on preoperative imaging / Am J Transplant 7:2587~2596
Mazzaferro V / 2009 / Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis / Lancet Oncol 10:35~43
Kneuertz PJ / 2012 / Multidisciplinary management of recurrent hepatocellular carcinoma following liver transplantation / J Gastrointest Surg 16:874~881
Mazzaferro V / 1996 / Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis / N Engl J Med 334:693~699
Yao FY / 2007 / Liver transplantation for hepatocellular carcinoma : validation of the UCSF-expanded criteria based on preoperative imaging / Am J Transplant 7:2587~2596
Mazzaferro V / 2009 / Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis / Lancet Oncol 10:35~43
Kneuertz PJ / 2012 / Multidisciplinary management of recurrent hepatocellular carcinoma following liver transplantation / J Gastrointest Surg 16:874~881
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