지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Selenium (Se) is known as an antioxidant mineral and heme iron is a major source for iron intake which can promote carcinogenesis in the body. This study was to investigate the effect of Se on heme-aggravated colon carcinogenesis in mice. Three experimental groups included control [normal diet + AOM (10 mg/kg body weight in saline)/DSS (2% in the drinking water)], [AOM/DSS + hemin (534 mg/kg body weight in CMC)], and [AOM/DSS + hemin + Se (2.82 mg/kg diet in CMC)] groups. Colonic mucosa were stained with 0.3% methylene blue and the colonic polyps, aberrant crypt (AC) and aberrant crypt foci (ACF) were counted. Lipid peroxidation in liver was evaluated by the thiobarbituric acid-reactive substances (TBARS) assay. The number of polyps in the hemin + Se group was 31.6% lower than that in the control group, and 41.4% lower than that in the hemin group. The number of AC in the hemin + Se group was 42.8% lower than that in the control group, and 49.1% lower than that in the hemin group. The number of ACF in the hemin + Se group was 49.0% lower than that in the control group, 45.7% than that in the hemin group. Hepatic TBARS level in the hemin + Se group was significantly low compared with the control group or the hemin group (p<0.05). These findings suggest that Se treatment may be protective against colon carcinogenesis promoted by a high heme-containing diet.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of ascorbic acid and hemin on experimental colon carcinogenesis in mice
Journal of Biomedical and Translational Research
2020 .01
-
Effect of hemin and ascorbic acid on colonic pre-neoplastic lesions induced by azoxymethane in mice
예방수의학회지
2017 .12
-
Effect of hemin and zinc on experimental colon carcinogenesis in mice
예방수의학회지
2019 .01
-
Effect of calcium on the formation of colonic pre-neoplastic lesions induced by azoxymethane and hemin in mice
예방수의학회지
2018 .03
-
Characterization of hemin-binding of oral streptococci
Oral Biology Research
2022 .09
-
Epigallocatechin-3-gallate suppresses hemin-aggravated colon carcinogenesis through Nrf2-inhibited mitochondrial reactive oxygen species accumulation
Journal of Veterinary Science
2022 .09
-
Characterization of the hemin-binding property of Porphyromonas endodontalis
Oral Biology Research
2021 .01
-
Heme effects of hemin on growth of peridontopathogens
구강회복응용과학지
2021 .03
-
Suppressive effects of pectin on colitis-associated colon carcinogenesis
Journal of Biomedical and Translational Research
2021 .12
-
Protective effect of stevia plant extract against experimental colon carcinogenesis in mice
Journal of Biomedical and Translational Research
2020 .01
-
Effect of iron overload with ascorbic acid on experimental coloncarcinogenesis in mice
Journal of Biomedical and Translational Research
2017 .12
-
Protective effect of stevia extract against experimental colon carcinogenesis in an animal model of mouse
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Characterization of Congo red binding in Streptococcus gordonii
Oral Biology Research
2021 .12
-
Effects of calcium on the formation of preneoplastic lesions in a mouse model of colon carcinogenesis
예방수의학회지
2015 .03
-
Protective effects of folic acid on colon carcino genesis induced by azoxymethane in mice
Journal of Biomedical and Translational Research
2021 .09
-
Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development
Cancer Research and Treatment
2019 .01
-
The Effect of Sex on the Azoxymethane/Dextran Sulfate Sodium-treated Mice Model of Colon Cancer
대한암예방학회지
2016 .01
-
Adequate Dextran Sodium Sulfate-induced Colitis Model in Mice and Effective Outcome Measurement Method
대한암예방학회지
2015 .01
-
Analysis of Correlation between Thyroid Cancer Incidence and Socioeconomic Status Using 10-year Sample Cohort Database
The Journal of Endocrine Surgery
2019 .01
-
American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice
Journal of Ginseng Research
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0