지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.4
- 수록면
- 109 - 113 (5page)
- DOI
- 10.47429/lmo.2023.13.2.109
이용수
초록· 키워드
오류제보하기
T-lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy associated with poor outcomes. The genetic background of T-ALL is widely heterogeneous and the TAL1 gene is overexpressed in approximately half of all cases. A submicroscopic interstitial deletion on chromosome 1p33 results in STIL-TAL1 fusion, causing inappropriate overexpression of TAL1, which promotes T cell leukemogenesis. T-ALL with STIL-TAL1 exhibits distinct characteristics, such as a mature cortical T cell immunophenotype, low incidence of NOTCH1 mutation, privileged association with PTEN inactivation, deletion of 6q14–q16, MYC translocation, high leukocyte count, poor response to treatment, and low event-free survival. However, the clinical relevance and prognostic value of this rearrangement remain unclear. Here, we report the first case of T-ALL with a 1p33 deletion resulting in STIL-TAL1 fusion in Korea, which was detected by reverse transcriptase-polymerase chain reaction and confirmed by chromosomal microarray analysis.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A Case of STIL-TAL1 -positive T-lymphoblastic Leukemia With a Minor Philadelphia-positive Clone
Annals of Laboratory Medicine
2023 .01
-
A Case of Therapy-Related Acute Leukemia With Mixed Phenotype With BCR-ABL1 After Treatment of Diffuse Large B-Cell Lymphoma
Annals of Laboratory Medicine
2017 .01
-
FcrR3A-158 Polymorphism and Stromal Tumor-Infiltrating Lymphocytes and Survival among Patients with Metastatic HER2-Positive Breast Cancer Receiving Trastuzumab-Based Treatment
Journal of Breast Cancer
2018 .01
-
Promoter methylation and expression levels of selected hematopoietic genes in pediatric B-cell acute lymphoblastic leukemia
Blood Research
2015 .01
-
Effects of e2f3 gene deletion in mice
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Submicroscopic Deletions of Immunoglobulin Heavy Chain Gene (IGH) in Precursor B Lymphoblastic Leukemia with IGH Rearrangements
Annals of Laboratory Medicine
2015 .01
-
The First Case of B-lymphoblastic Leukemia Associated With t(7;8)(q34;p11.2) and FGFR1 Rearrangement
Annals of Laboratory Medicine
2022 .07
-
A Rare Case of Pediatric T Lymphoblastic Leukemia With t(11;17)(q23;q21) Involving Mixed-Lineage Leukemia Gene Rearrangement
Annals of Laboratory Medicine
2016 .01
-
T cell acute lymphoblastic leukemia with t(11;14)(p13;q11) and trisomy 8
Blood Research
2021 .09
-
Therapy-related acute myeloid leukemia in a patient with B-cell acute lymphoblastic leukemia
Blood Research
2021 .12
-
Two Cases of Acute Lymphoblastic Leukemia with an e1a3 BCR-ABL1 Fusion Transcript
Annals of Laboratory Medicine
2015 .01
-
A Case of B-cell Precursor Acute Lymphoblastic Leukemia with the t(14;22)(q32;q11) Presenting Hyperleukocytosis
Clinical Pediatric Hematology-Oncology
2022 .10
-
Prenatal diagnosis of 4p deletion syndrome: A case series report
Journal of genetic medicine
2017 .01
-
The e1a3 BCR-ABL1 Fusion Transcript in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Annals of Laboratory Medicine
2015 .01
-
Prognostic factors and treatment of pediatric acute lymphoblastic leukemia
Clinical and Experimental Pediatrics
2017 .01
-
Multiplex RT-PCR Assay for Detection of Common Fusion Transcripts in Acute Lymphoblastic Leukemia and Chronic Myeloid Leukemia Cases
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Deletion of 20p13 and Duplication of 20p13p12.3 in a Patient with Delayed Speech and Development
Annals of Laboratory Medicine
2018 .01
-
FHIT Gene Expression in Acute Lymphoblastic Leukemia and its Clinical Significance
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
14q12q13.3 Deletion Diagnosed Using Chromosomal Microarray Analysis in an Infant Showing Seizures, Hypoplasia of the Corpus Callosum, and Developmental Delay
Neonatal medicine
2020 .01
-
De novo interstitial deletion of 15q22q23 with global developmental delay and hypotonia: the first Korean case
Clinical and Experimental Pediatrics
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0