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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 64 - 66 (3page)
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Dear Editor, T lymphoblastic leukemia (T-ALL) comprises 10-15% of pediatric ALL cases and is known to be a clinically and genetically heterogeneous disease [1]. Recent studies have presented various cytogenetic abnormalities in T-ALL. The alterations often present as reciprocal translocations implicated in several transcriptional factor genes and lead to arrest during T-cell differentiation [1, 2]. Although cytogenetic aberrations are known to be critical in leukemogenesis of many hematologic malignancies, the relationships between these aberrations and the prognosis are not well understood in T-ALL except for t(11;19), a mixed-lineage leukemia gene (MLL)-ENL fusion related to favorable prognosis [3]. Here, we report a very rare case of pediatric T-ALL with t(11;17)(q23;q21) involving MLL rearrangement, which has not been previously reported in Korea.
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참고문헌 (10)
참고문헌 신청
Patrick K / 2015 / Update on biology and treatment of T-cell acute lymphoblastic leukaemia / Curr Opin Pediatr 27:44~49
Meijerink JP / 2010 / Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia / Best Pract Res Clin Haematol 23:307~318
Pui CH / 2004 / Childhood and adolescent lymphoid and myeloid leukemia / Hematology Am Soc Hematol Educ Program :118~145
Borowitz MJ / 2008 / WHO classification of tumours of haematopoietic and lymphoid tissues / IARC :176~178
Ferrando AA / 2003 / Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation / Blood 102:262~268
Meijerink JP / 2010 / Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia / Best Pract Res Clin Haematol 23:307~318
Pui CH / 2004 / Childhood and adolescent lymphoid and myeloid leukemia / Hematology Am Soc Hematol Educ Program :118~145
Borowitz MJ / 2008 / WHO classification of tumours of haematopoietic and lymphoid tissues / IARC :176~178
Ferrando AA / 2003 / Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation / Blood 102:262~268
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