지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국병원약사회 병원약사회지 병원약사회지 제40권 제2호
- 발행연도
- 2023.5
- 수록면
- 183 - 194 (12page)
- DOI
- https://doi.org/10.32429/jkshp.2023.40.2.003
이용수
초록· 키워드
오류제보하기
Background : Graft-versus-host disease (GVHD) is a complication reported in 30–50% of patients who receive homologous hematopoietic stem cell transplantation. Although systemic corticosteroids are recommended as primary treatment, approximately 50% develop steroid-refractory GVHD (SR-GVHD) with high mortality. In May 2022, ruxolitinib was approved by the Ministry of Food and Drug Safety for the treatment of SR-GVHD, but there is limited data on treatment responses in Korean patients. The purpose of this study was to evaluate the effectiveness of ruxolitinib in patients with SR-GVHD.
Methods : We enrolled patients with GVHD who had received ruxolitinib treatement at Severance Hospital between January 2017 to July 2022. We evaluated the overall response rate (ORR) and non-relapse mortality (NRM) at the time of ruxolitinib discontinuation. Patients and GVHD characteristics were analyzed according to the responder and non-responder groups of ruxolitinib, and the steroid-sparing effect was estimated based on whether the co-administered steroids were reduced.
Results : There were no significant differences in baseline patient characteristics and GVHD characteristics between the responder and non-responder groups. The overall responsive rate (ORR) for ruxolitinib was 50% (22 of 44 patients). During the administration of ruxolitinib, 91% of responders and 46% of non-responders experienced a reduction of steroid dose reduction (p<0.01). The NRM was 10% in the responder group and 64% in the non-responder group (p<0.01), and the main cause of death was infection.
Conclusion : The results demonstrate that ruxolitinib has a steroid-sparing effect in patients with SR-GVHD, as evidenced by the higher number of patients who experienced steroid dose reduction and the lower NRM in responders than non-responders. This suggests the possibility of reducing steroid-induced infection risk and mortality.
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