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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 326 - 334 (9page)
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Antibiotic resistance (AR) is a silent pandemic that kills millionsworldwide. Although the development of new therapeutic agentsagainst antibiotic resistance is in urgent demand, this has presenteda great challenge, especially for Gram-negative bacteriathat have inherent drug-resistance mediated by impermeableouter membranes and multidrug efflux pumps that actively extrudevarious drugs from the bacteria. For the last two decades,multidrug efflux pumps, including AcrAB−TolC, the most clinicallyimportant efflux pump in Gram-negative bacteria, havedrawn great attention as strategic targets for re-sensitizing bacteriato the existing antibiotics. This article aims to provide aconcise overview of the AcrAB−TolC operational mechanism,reviewing its architecture and substrate specificity, as well asthe recent development of AcrAB−TolC inhibitors.
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