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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 348 - 353 (6page)
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efflux transporter expressions following status epilepticus (SE).
In the hippocampus and piriform cortex (PC), vasogenic edema peaked 3-4 days after SE. The expression of breast cancer resistance protein (BCRP), multidrug resistance protein-4 (MRP4), and p-glycoprotein (p-GP) were decreased 4 days after SE when vasogenic edema was peaked, but subsequently increased 4 weeks after SE. Multidrug resistance protein-1 (MRP1) expression gradually decreased in endothelial cells until 4 weeks after SE.
These findings indicate that SE-induced vasogenic edema formation transiently reduced drug efflux pump expressions in endothelial cells. Subsequently, during recovery of vasogenic edema drug efflux pump expressions were differentially upregulated in astrocytes, neuropils, and endothelial cells. Therefore, we suggest that vasogenic edema formation may be a risk factor in pharmacoresistent epilepsy.
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참고문헌 (23)
참고문헌 신청
Aronica E / 2003 / Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and
Bankstahl JP / 2008 / Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus / Epilepsy Res 82 : 70 ~ 85
Begley DJ / 2004 / ABC transporters and the blood-brain barrier / Curr Pharm Des 10 : 1295 ~ 1312
Brandt C / 2006 / The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy / Neurobiol Dis 24 : 202 ~
Clinckers R / 2005 / Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use
Bankstahl JP / 2008 / Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus / Epilepsy Res 82 : 70 ~ 85
Begley DJ / 2004 / ABC transporters and the blood-brain barrier / Curr Pharm Des 10 : 1295 ~ 1312
Brandt C / 2006 / The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy / Neurobiol Dis 24 : 202 ~
Clinckers R / 2005 / Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: concomitant use
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